Inhibition of nitric oxide synthesis reduces intravenous cocaine self-administration in the rat

被引：33
作者：
Pulvirenti, L
Balducci, C
Koob, GF
机构：
[1] Scripps Res Inst, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA
[2] FDN IST NEUROL C MONDINO, PAVIA, ITALY
来源：
NEUROPHARMACOLOGY | 1996年 / 35卷 / 12期
关键词：
cocaine; nitric oxide; drug dependence; l-NAME;
D O I：
10.1016/S0028-3908(96)00152-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of a blockade of nitric oxide synthesis were studied in rats trained to self-administer cocaine intravenously. Pretreatment with Ng-nitro-1-arginine methyl ester (1-NAME; 10-50 mg/kg, intraperitoneally, twice daily for 4 days), significantly and dose-dependently suppressed the maintenance of intravenous cocaine self-administration and the absolute reward magnitude of cocaine. These results suggest that nitric oxide may play a role in cocaine abuse and dependence. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：1811 / 1814
页数：4
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