ProBiS-ligands: a web server for prediction of ligands by examination of protein binding sites

被引：59

作者：

Konc, Janez ^{[1
]}

Janezic, Dusanka ^{[2
]}

机构：

[1] Natl Inst Chem, Ljubljana 1000, Slovenia

[2] Univ Primorska, Fac Math Nat Sci & Informat Technol, Koper 6000, Slovenia

来源：

NUCLEIC ACIDS RESEARCH | 2014年 / 42卷 / W1期

关键词：

ALGORITHM; DOCKING; IDENTIFICATION;

D O I：

10.1093/nar/gku460

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ProBiS-ligands web server predicts binding of ligands to a protein structure. Starting with a protein structure or binding site, ProBiS-ligands first identifies template proteins in the Protein Data Bank that share similar binding sites. Based on the superimpositions of the query protein and the similar binding sites found, the server then transposes the ligand structures from those sites to the query protein. Such ligand prediction supports many activities, e.g. drug repurposing. The ProBiS-ligands web server, an extension of the ProBiS web server, is open and free to all users

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收藏

页码：W215 / W220

页数：6

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