Arsenic carcinogenicity: Relevance of c-Src activation

被引：28
|
作者：
Simeonova, PP [1 ]
Luster, MI [1 ]
机构：
[1] NIOSH, Toxicol & Mol Biol Branch, Hlth Effects Lab Div, Morgantown, WV 26505 USA
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2002年 / 234卷 / 01期
关键词：
gene expression; reactive oxygen species; skin cancer; bladder cancer;
D O I：
10.1023/A:1015971118012
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Environmental and occupational exposure to arsenic is associated with increased risk of skin, urinary bladder and respiratory tract cancers. Increasing evidence indicates that arsenic acts at the level of tumor promotion by modulating the signaling pathways responsible for cell growth. One of this pathways might include c-Src dependent EGFR and MAPK activation.
引用
收藏
页码：277 / 282
页数：6
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