Modulatory effects of quercetin on proliferation and differentiation of the human colorectal cell line Caco-2

被引：54
作者：
Dihal, Ashwin A.
Woutersen, Ruud A.
Van Ommen, Ben
Rietjens, Ivonne M. C. M.
Stierum, Rob H.
机构：
[1] TNO, Qual Life, Dept Physiol Sci, NL-3700 AJ Zeist, Netherlands
[2] TNO, Qual Life, Dept Toxicol & Appl Pharmacol, NL-3700 AJ Zeist, Netherlands
[3] Univ Wageningen & Res Ctr, Div Toxicol, Wageningen, Netherlands
来源：
CANCER LETTERS | 2006年 / 238卷 / 02期
关键词：
quercetin; proliferation; differentiation; metabolism; colorectal cancer; Caco-2;
D O I：
10.1016/j.canlet.2005.07.007
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The effect of the dietary flavonoid quercetin was investigated on proliferation and differentiation of the human colon cancer cell line Caco-2. Confluent Caco-2 monolayers exposed to quercetin showed a biphasic effect on cell proliferation and a decrease in cell differentiation (0.001 < P < 0.05). During differentiation Caco-2 cells formed 5 phase II metabolites, of which the amount of 4'-O-methyl-quercetin-3'-O-glucuronide correlated with the differentiation grade (r = 0.99, P < 0.003). The increment of cell proliferation at low quercetin concentrations and the decrease in cell differentiation are effects opposite to what would be expected for a functional food ingredient with anti-carcinogenic potential. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：248 / 259
页数：12
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