DEGRADATION AND TRANSFORMATION OF 17α-ESTRADIOL IN WATER-SEDIMENT SYSTEMS UNDER CONTROLLED AEROBIC AND ANAEROBIC CONDITIONS

被引：15

作者：

Robinson, Joseph A. ^{[1
]}

Ma, Qingli ^{[2
]}

Staveley, Jane P. ^{[3
]}

Smolenski, Walter J. ^{[4
]}

Ericson, Jon ^{[5
]}

机构：

[1] Zoetis, Kalamazoo, MI USA

[2] Exponent, Washington, DC USA

[3] Exponent, Cary, NC USA

[4] Phase II, Kalamazoo, MI USA

[5] Pfizer, Worldwide R&D, PDM Environm Sci, Groton, CT USA

来源：

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY | 2017年 / 36卷 / 03期

关键词：

Estrogenic compound; Steroid transformation; Estradiol; Veterinary medicine; Synovex (R) ONE; REPRODUCTIVE ENDOCRINOLOGY; STEROID-HORMONES; 17-BETA-ESTRADIOL; ESTRADIOL; GROWTH; FATE; ESTRONE; RIVER; BIODEGRADATION; TRENBOLONE;

D O I：

10.1002/etc.3383

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

One of the principal metabolites in cattle excreta following the administration of Synovex((R)) ONE, which contains estradiol benzoate and trenbolone acetate, is 17 alpha-estradiol. As part of the environmental assessment of the use of Synovex ONE, data were generated to characterize the fate of 17 alpha-estradiol in the environment. Studies were conducted to determine the degradation and transformation of 17 alpha-[C-14]-estradiol in 2 representative water-sediment systems each under aerobic and anaerobic conditions. The same transformation products-estriol, 17 beta-estradiol, and estrone-were formed, principally in the sediment phase, under both conditions in both systems. From the production of these transformation products, the 50% disappearance time (DT50) values of estrone and 17 beta-estradiol were determined, along with the DT50 values of 17 alpha-estradiol and the total drug (17 alpha-estradiol+17 beta-estradiol+estrone). The results indicate that 17 alpha-[C-14]-estradiol was more persistent under anaerobic conditions than under aerobic conditions and that 17 alpha-[C-14]-estradiol was less persistent than its transformation products. The DT50 values for the total system (aqueous and sediment phases) and for the total residues (17 alpha- estradiol, 17 beta-estradiol, and estrone) were selected for use in modeling the environmental fate of estradiol benzoate. For aerobic degradation in the water-sediment system, the DT50 was 31.1 d, and it was 107.8 d for the anaerobic system. (C) 2016 SETAC

引用

页码：621 / 629

页数：9

共 35 条

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