Genetic susceptibility in cervical cancer: From bench to bedside

被引：47

作者：

Bahrami, Afsane ^{[1
,2
,3
]}

Hasanzadeh, Malihe ^{[4
]}

Shahidsales, Soodabeh ^{[5
]}

Farazestanian, Marjaneh ^{[4
]}

Hassanian, Seyed Mahdi ^{[2
,6
]}

Ahmadi, Mehrdad Moetamani ^{[1
]}

Maftouh, Mina ^{[2
]}

Gharib, Masoumeh ^{[7
]}

Yousefi, Zohreh ^{[4
]}

Kadkhodayan, Sima ^{[4
]}

Ferns, Gordon A. ^{[8
]}

Avan, Amir ^{[2
]}

机构：

[1] Mashhad Univ Med Sci, Sch Med, Dept Modern Sci & Technol, Mashhad, Iran

[2] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Iran

[3] Mashhad Univ Med Sci, Student Res Comm, Fac Med, Mashhad, Iran

[4] Mashhad Univ Med Sci, Dept Gynecol Oncol, Woman Hlth Res Ctr, Mashhad, Iran

[5] Mashhad Univ Med Sci, Canc Res Ctr, Mashhad, Iran

[6] Mashhad Univ Med Sci, Dept Med Biochem, Fac Med, Mashhad, Iran

[7] Mashhad Univ Med Sci, Dept Pathol, Fac Med, Mashhad, Iran

[8] Brighton & Sussex Med Sch, Div Med Educ, Brighton, E Sussex, England

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2018年 / 233卷 / 03期

关键词：

cervical cancer; GWAS; single nucleotide polymorphism; susceptibility; GENOME-WIDE ASSOCIATION; SINGLE NUCLEOTIDE POLYMORPHISMS; NEOADJUVANT CHEMOTHERAPY; CHINESE POPULATION; P73; G4C14-TO-A4T14; CODON; 72; RISK; VARIANTS; WOMEN; RECEPTOR;

D O I：

10.1002/jcp.26019

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cervical cancer (CC) is the third most common malignancy in women globally, and persistent infection with the oncogenic human papillomaviruses (HPV) is recognized as the major risk factor. The pathogenesis of CC relies on the interplay between the tumorigenic properties of the HPV and host factors. Host-related genetic factors, including the presence of susceptibility loci for cervix tumor is substantial importance. Preclinical and genome-wide association studies (GWAS) have reported the associations of genetic variations in several susceptibility loci for the development of cervical cancer. However, many of these reports are inconsistent. In this review, we discuss the findings to date of candidate gene association studies, and GWAS in cervical cancer. The associations between these genetic variations with response to chemotherapy are also discussed.

引用

页码：1929 / 1939

页数：11

共 76 条

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