Synthesis of Acid-Labile PEG and PEG-Doxorubicin-Conjugate Nanoparticles via Brush-First ROMP

被引：85
作者：
Gao, Angela X. [1 ]
Liao, Longyan [1 ]
Johnson, Jeremiah A. [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
ACS MACRO LETTERS | 2014年 / 3卷 / 09期
基金：
美国国家卫生研究院;
关键词：
CONTROLLED-RELEASE; DRUG-DELIVERY; POLYMERS; METATHESIS; PH; DEGRADATION; PLATFORM;
D O I：
10.1021/mz5004097
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A panel of acid-labile bis-norbornene cross-linkers was synthesized and evaluated for the formation of acid-degradable brush-arm star polymers (BASPs) via the brush-first ring-opening metathesis polymerization (ROMP) method. An acetal-based cross-linker was identified that, when employed in conjunction with a poly(ethylene glycol) (PEG) macromonomer, provided highly controlled BASP formation reactions. A combination of this new cross-linker with a novel doxorubicin (DOX)-branch-PEG macromonomer provided BASPs that simultaneously degrade and release cytotoxic DOX in vitro.
引用
收藏
页码：854 / 857
页数：4
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