Iron dysregulation in Huntington's disease

被引：95
作者：
Muller, Michelle [1 ,2 ]
Leavitt, Blair R. [1 ,2 ,3 ,4 ]
机构：
[1] Univ British Columbia, Dept Med Genet, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada
[2] Womens & Childrens Hosp, Vancouver, BC V5Z 4H4, Canada
[3] Univ British Columbia Hosp, Dept Med, Div Neurol, Vancouver, BC V6T 1W5, Canada
[4] Univ British Columbia, Brain Res Ctr, Vancouver, BC V5Z 4H4, Canada
来源：
JOURNAL OF NEUROCHEMISTRY | 2014年 / 130卷 / 03期
关键词：
huntingtin; Huntington's disease; iron; magnetic resonance imaging; microglia; neurodegeneration; WILD-TYPE HUNTINGTIN; AGE-OF-ONSET; BRAIN TRANSITION-METALS; NMDA RECEPTOR FUNCTION; D-ASPARTATE RECEPTORS; N-TERMINAL FRAGMENTS; COMPLEX-II DEFECTS; RAS HOMOLOG RHES; MUTANT-HUNTINGTIN; OXIDATIVE STRESS;
D O I：
10.1111/jnc.12739
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Huntington's disease (HD) is one of many neurodegenerative diseases with reported alterations in brain iron homeostasis that may contribute to neuropathogenesis. Iron accumulation in the specific brain areas of neurodegeneration in HD has been proposed based on observations in post-mortem tissue and magnetic resonance imaging studies. Altered magnetic resonance imaging signal within specific brain regions undergoing neurodegeneration has been consistently reported and interpreted as altered levels of brain iron. Biochemical studies using various techniques to measure iron species in human samples, mouse tissue, or in vitro has generated equivocal data to support such an association. Whether elevated brain iron occurs in HD, plays a significant contributing role in HD pathogenesis, or is a secondary effect remains currently unclear.
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收藏
页码：328 / 350
页数：23
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共 283 条
[1]   Novel treatment of excitotoxicity: targeted disruption of intracellular signalling from glutamate receptors [J].
Aarts, MM ;
Tymianski, M .
BIOCHEMICAL PHARMACOLOGY, 2003, 66 (06) :877-886
[2]   Chemistry and biology of eukaryotic iron metabolism [J].
Aisen, P ;
Enns, C ;
Wessling-Resnick, M .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2001, 33 (10) :940-959
[3]   Protein oxidation in Huntington disease affects energy production and vitamin B6 metabolism [J].
Alba Sorolla, Ma ;
Jose Rodriguez-Colman, Ma ;
Tamarit, Jordi ;
Ortega, Zaira ;
Lucas, Jose J. ;
Ferrer, Isidre ;
Ros, Joaquim ;
Cabiscol, Elisa .
FREE RADICAL BIOLOGY AND MEDICINE, 2010, 49 (04) :612-621
[4]   ABNORMALITIES OF STRIATAL PROJECTION NEURONS AND N-METHYL-D-ASPARTATE RECEPTORS IN PRESYMPTOMATIC HUNTINGTONS-DISEASE [J].
ALBIN, RL ;
YOUNG, AB ;
PENNEY, JB ;
HANDELIN, B ;
BALFOUR, R ;
ANDERSON, KD ;
MARKEL, DS ;
TOURTELLOTTE, WW ;
REINER, A .
NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (18) :1293-1298
[5]   GENETICS AND MOLECULAR-BIOLOGY OF HUNTINGTONS-DISEASE [J].
ALBIN, RL ;
TAGLE, DA .
TRENDS IN NEUROSCIENCES, 1995, 18 (01) :11-14
[6]   Hepcidin regulation by innate immune and infectious stimuli [J].
Armitage, Andrew E. ;
Eddowes, Lucy A. ;
Gileadi, Uzi ;
Cole, Suzanne ;
Spottiswoode, Natasha ;
Selvakumar, Tharini Ashtalakshmi ;
Ho, Ling-Pei ;
Townsend, Alain R. M. ;
Drakesmith, Hal .
BLOOD, 2011, 118 (15) :4129-4139
[7]   Ferritins: A family of molecules for iron storage, antioxidation and more [J].
Arosio, Paolo ;
Ingrassia, Rosaria ;
Cavadini, Patrizia .
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2009, 1790 (07) :589-599
[8]   Protein aggregates in Huntington's disease [J].
Arrasate, Montserrat ;
Finkbeiner, Steven .
EXPERIMENTAL NEUROLOGY, 2012, 238 (01) :1-11
[9]   Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity [J].
Atwal, Randy Singh ;
Xia, Jianrun ;
Pinchev, Deborah ;
Taylor, Jillian ;
Epand, Richard M. ;
Truant, Ray .
HUMAN MOLECULAR GENETICS, 2007, 16 (21) :2600-2615
[10]   The HD mutation causes progressive lethal neurological disease in mice expressing reduced levels of huntingtin [J].
Auerbach, W ;
Hurlbert, MS ;
Hilditch-Maguire, P ;
Wadghiri, YZ ;
Wheeler, VC ;
Cohen, SI ;
Joyner, AL ;
MacDonald, ME ;
Turnbull, DH .
HUMAN MOLECULAR GENETICS, 2001, 10 (22) :2515-2523
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