Anti-inflammatory and related pharmacological activities of the n-BuOH subfraction of mushroom Phellinus linteus

被引：104

作者：

Kim, SH

Song, YS

Kim, SK

Kim, BC

Lim, CJ

Park, EH ^{[1
]}

机构：

[1] Sookmyung Womens Univ, Coll Pharm, Seoul 140742, South Korea

[2] Korea Inst Sci & Technol, Bioanal & Biotransformat Res Ctr, Seoul 130650, South Korea

[3] Kangwon Natl Univ, Div Life Sci, Chunchon 200701, South Korea

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2004年 / 93卷 / 01期

关键词：

Phellinus linteus; anti-inflammatory; antinociceptive; anti-angiogenic; chorioallantoic membrane; ear edema; folk medicine;

D O I：

10.1016/j.jep.2004.03.048

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

This study aimed to elucidate the anti-inflammatory and related activities of mushroom Phellinus linteus. The results show that the EtOH extract of Phellinus linteus (PLE) dose-dependently inhibited the mouse ear edema induced by croton oil. Among PLE subfractions, the n-BuOH subtraction showed highest anti-inflammatory activity in croton oil-induced ear edema test. The n-BuOH subtraction also showed highest inhibitory activity on the chick embryo chorioallantoic membrane (CAM) angiogenesis in a dose-dependent manner. PLE could significantly reduce the number of writhing induced by acetic acid in mice, indicating that PLE possesses potent antinociceptive effect mediated by its anti-inflammatory activity. Mycelial extract of six different Phellinus strains were found to contain anti-angiogenic activity in the CAM assay. These results suggest that Phellinus linteus has anti-inflammatory and antinociceptive activities, in addition to its anti-angiogenic activity. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：141 / 146

页数：6

共 18 条

[1] The roles of ERK1/2 and p38 MAP kinases in the preventive mechanisms of mushroom Phellinus linteus against the inhibition of gap junctional intercellular communication by hydrogen peroxide [J].