Hemodynamic Aging as the Consequence of Structural Changes Associated with Early Vascular Aging (EVA)

被引:2
作者
Nilsson, Peter M. [1 ]
机构
[1] Lund Univ, Skane Univ Hosp, Dept Clin Sci, S-20502 Malmo, Sweden
来源
AGING AND DISEASE | 2014年 / 5卷 / 02期
关键词
aging; arterial stiffness; cardiac; blood pressure; haemodynamic; vasculature; PULSE-WAVE VELOCITY; BLOOD-PRESSURE; ARTERIAL STIFFNESS; AORTIC STIFFNESS; CARDIOVASCULAR RISK; HYPERTENSION; VARIABILITY; DISEASE; DRUGS;
D O I
暂无
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
An increase in peripheral vascular resistance at rest is not routinely observed in healthy older persons, but often associated with increased stiffness of central elastic arteries, as hallmarks of aging effects on the vasculature, referred to as early vascular aging (EVA). In clinical practice, the increased arterial stiffness translates into increased brachial and central systolic blood pressure and corresponding pulse pressure in subjects above 50 years of age, as well as increased carotid-femoral pulse wave velocity (c-f PWV), a marker of arterial stiffness. A c-f PWV value >= 10 m/s is currently defined as a threshold for increased cardiovascular risk, based on consensus statement from 2012. Prevention and treatment strategies include a healthy lifestyle and the control of risk factors via appropriate drug therapy to achieve vascular protection related to EVA. New drugs are under development for vascular protection, for example the selective Angiotensin II (AT2) receptor agonist called compound 21. One target group for early intervention could be members of risk families including subjects with early onset cardiovascular disease.
引用
收藏
页码:109 / 113
页数:5
相关论文
共 50 条
  • [21] Frequency of early vascular aging and associated risk factors among an adult population in Latin America: the OPTIMO study
    Botto, Fernando
    Obregon, Sebastian
    Rubinstein, Fernando
    Scuteri, Angelo
    Nilsson, Peter M.
    Kotliar, Carol
    JOURNAL OF HUMAN HYPERTENSION, 2018, 32 (03) : 219 - 227
  • [22] The EVA (Early Vascular Aging) Study: Association of Central Obesity With Worse Arterial Health After Preeclampsia
    Paquin, Amelie
    Werlang, Ana
    Coutinho, Thais
    JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2023, 12 (21):
  • [23] Aortic Aging in ESRD: Structural, Hemodynamic, and Mortality Implications
    London, Gerard M.
    Safar, Michel E.
    Pannier, Bruno
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2016, 27 (06): : 1837 - 1846
  • [24] Vascular Aging A Tale of EVA and ADAM in Cardiovascular Risk Assessment and Prevention
    Nilsson, Peter M.
    Boutouyrie, Pierre
    Laurent, Stephane
    HYPERTENSION, 2009, 54 (01) : 3 - 10
  • [25] Vascular aging and hemodynamic stability in the intraoperative period
    Gragasin, Ferrante S.
    Bourque, Stephane L.
    Davidge, Sandra T.
    FRONTIERS IN PHYSIOLOGY, 2012, 3
  • [26] Assessment of Early Vascular Aging Ambulatory Score (EVAAs): A Large Population-based External Validation Study
    Antza, Christina
    Potoupni, Victoria
    Akrivos, Evangelos
    Stabouli, Stella
    Kotsis, Vasilios
    CURRENT VASCULAR PHARMACOLOGY, 2024, 22 (06) : 417 - 425
  • [27] Early Vascular Aging in Obese Individuals with Low Cardiovascular Health
    Cunha, Michelle Rabello
    Mattos, Samanta
    Klein, Marcia R. S. T.
    Neves, Mario Fritsch
    HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION, 2023, 30 (01) : 45 - 54
  • [28] Racial differences of early vascular aging in children and adolescents
    Ruan Kruger
    Lebo Francina Gafane-Matemane
    Juliana Kagura
    Pediatric Nephrology, 2021, 36 : 1087 - 1108
  • [29] Early Vascular Aging in Children With Tuberous Sclerosis Complex
    Skrzypczyk, Piotr
    Wabik, Anna Maria
    Szyszka, Michal
    Jozwiak, Sergiusz
    Bombinski, Przemyslaw
    Jakimow-Kostrzewa, Aleksandra
    Brzewski, Michal
    Panczyk-Tomaszewska, Malgorzata
    FRONTIERS IN PEDIATRICS, 2021, 9
  • [30] Early vascular aging in the HIV infected: Is arterial stiffness assessment the ideal tool?
    Fourie, Carla M. T.
    Schutte, Aletta E.
    VIRULENCE, 2017, 8 (07) : 1075 - 1077