The New Insight into the Role of Antimicrobial Proteins-Alarmins in the Immunopathogenesis of Psoriasis

被引:47
作者
Batycka-Baran, A. [1 ]
Maj, J. [1 ]
Wolf, R. [2 ]
Szepietowski, J. C. [1 ]
机构
[1] Wroclaw Med Univ, Dept Dermatol Venereol & Allergol, PL-50368 Wroclaw, Poland
[2] Univ Munich, Dept Dermatol & Allergol, D-80539 Munich, Germany
关键词
PLASMACYTOID DENDRITIC CELLS; PEPTIDE LL-37; CATHELICIDIN LL-37; MOLECULAR-CLONING; VITAMIN-D; GENE-EXPRESSION; ALPHA-DEFENSINS; INNATE IMMUNITY; SKIN; RECEPTOR;
D O I
10.1155/2014/628289
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The pathognesis of psoriasis still remains not fully elucidated. Recent advances favor the idea that interactions between innate and adaptive immune response drive inflammatory process in this disease. Innate antimicrobial peptides and proteins (AMPs) are diverse group of small molecules that provide the first line of defense against invading pathogens. In recent years, the novel functions ofAMPs have been identified. There are three subclasses among AMPs that have gained the special interest as a potentially important player in the pathogenesis of psoriasis: cathelicidin, S100 proteins, and defensins. These AMPs have been shown to modulate and trigger host immune response in psoriasis acting as interplayer between innate and adaptive immune mechanisms. Overexpressed in psoriatic lesions, they prime immune cells for enhanced production of proinflammatory mediators and act as chemoattractant for leukocytes. Therefore, the novel term describing AMPs alarmins has been suggested. As multifunctional player in pathogenesis of psoriasis, AMPs may constitute potential target for therapeutic interventions. However, further investigations are required to establish the methods of downregulation of the aberrant proinflammatory functions of AMPs without increasing the risk of infections.
引用
收藏
页数:10
相关论文
共 87 条
[1]   The human antimicrobial and chemotactic peptides LL-37 and α-defensins are expressed by specific lymphocyte and monocyte populations [J].
Agerberth, B ;
Charo, J ;
Werr, J ;
Olsson, B ;
Idali, F ;
Lindbom, L ;
Kiessling, R ;
Jörnvall, H ;
Wigzell, H ;
Gudmundsson, GH .
BLOOD, 2000, 96 (09) :3086-3093
[2]   Effect of Narrowband Ultraviolet B Therapy on Serum Vitamin D and Cathelicidin (LL-37) in Patients with Chronic Plaque Psoriasis [J].
Al-Mutairi, Nawaf ;
Shaaban, Dalia .
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY, 2014, 18 (01) :43-48
[3]   Resident skin cells in psoriasis:: a special took at the pathogenetic functions of keratinocytes [J].
Albanesi, Cristina ;
De Pita, Ornella ;
Girolomoni, Giampiero .
CLINICS IN DERMATOLOGY, 2007, 25 (06) :581-588
[4]   Elevated serum levels of calcium-binding S100 proteins A8 and A9 reflect disease activity and abnormal differentiation of keratinocytes in psoriasis [J].
Benoit, S. ;
Toksoy, A. ;
Ahlmann, M. ;
Schmidt, M. ;
Sunderkoetter, C. ;
Foell, D. ;
Pasparakis, M. ;
Roth, J. ;
Goebeler, M. .
BRITISH JOURNAL OF DERMATOLOGY, 2006, 155 (01) :62-66
[5]   Toll-like receptor 4-dependent activation of dendritic cells by β-defensin 2 [J].
Biragyn, A ;
Ruffini, PA ;
Leifer, CA ;
Klyushnenkova, E ;
Shakhov, A ;
Chertov, O ;
Shirakawa, AK ;
Farber, JM ;
Segal, DM ;
Oppenheim, JJ ;
Kwak, LW .
SCIENCE, 2002, 298 (5595) :1025-1029
[6]   Structure-function relationships among human cathelicidin peptides: Dissociation of antimicrobial properties from host immunostimulatory activities [J].
Braff, MH ;
Hawkins, MA ;
Di Nardo, A ;
Lopez-Garcia, B ;
Howell, MD ;
Wong, C ;
Lin, K ;
Streib, JE ;
Dorschner, R ;
Leung, DYM ;
Gallo, RL .
JOURNAL OF IMMUNOLOGY, 2005, 174 (07) :4271-4278
[7]   Innate immunity and antimicrobial defense systems in psoriasis [J].
Buchau, Amanda S. ;
Gallo, Richard L. .
CLINICS IN DERMATOLOGY, 2007, 25 (06) :616-624
[8]   S100A15, an antimicrobial protein of the skin:: Regulation by E-coli through toll-like receptor 4 [J].
Buechau, Amanda S. ;
Hassan, Mohamed ;
Kukova, Gabriela ;
Lewerenz, Virginia ;
Kellermann, Sabine ;
Wuerthner, Jens U. ;
Wolf, Ronald ;
Walz, Markus ;
Gallo, Richard L. ;
Ruzicka, Thomas .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007, 127 (11) :2596-2604
[9]   Cytosolic sensing of extracellular self-DNA transported into monocytes by the antimicrobial peptide LL37 [J].
Chamilos, Georgios ;
Gregorio, Josh ;
Meller, Stephan ;
Lande, Roberto ;
Kontoyiannis, Dimitrios P. ;
Modlin, Robert L. ;
Gilliet, Michel .
BLOOD, 2012, 120 (18) :3699-3707
[10]   The Human Antimicrobial Peptide LL-37 Suppresses Apoptosis in Keratinocytes [J].
Chamorro, Clara I. ;
Weber, Gunther ;
Gronberg, Alvar ;
Pivarcsi, Andor ;
Stahle, Mona .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2009, 129 (04) :937-944