Preparation of Polysaccharide-Apatite Hybrid Microtubes Using Layer-by-Layer Assembly and Biomimetic Mineralization Process

被引:2
作者
Hashizume, Mineo [1 ,2 ]
Nishikawa, Tatsuya [2 ]
机构
[1] Tokyo Univ Sci, Dept Ind Chem, Fac Engn, Shinjuku Ku, Tokyo 1620826, Japan
[2] Tokyo Univ Sci, Grad Sch Chem Sci & Technol, Shinjuku Ku, Tokyo 1620826, Japan
关键词
Organic-Inorganic Hybrid; Microtube; Polysaccharide; Layer-by-Layer (LbL) Assembly; Hydroxyapatite (HAp); Simulated Body Fluid (SBF); TRANSFORM INFRARED-SPECTROSCOPY; BONE-LIKE APATITE; CALCIUM-PHOSPHATE; EARLY DEPOSITS; SOLID-PHASE; HYDROXYAPATITE; SCAFFOLDS; POLYETHYLENEIMINE; BIOMATERIALS; ENVIRONMENT;
D O I
10.1166/jnn.2014.8582
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Organic inorganic hybrid microtubes were prepared that consisted of polysaccharide inner layers and hydroxyapatite (HAp) outer layers. Poly(methyl methacrylate) (PMMA) fibers containing small amounts of polyethyleneimine (PEI) were used as templates for the layer-by-layer (LbL) assembly of chondroitin sulfate C and chitosan. HAp layers were then deposited on polysaccharide layer-coated fibers using biomimetic processes. PMMA-PEI fiber templates were removed by immersing the samples in chloroform. Examination of the resulting materials using various physical characterizations such as scanning electron microscopy, FT-IR spectroscopy, X-ray photoelectron spectroscopy, and X-ray diffraction studies supported the successful formation of the hybrid microtubes as designed. The results also showed that incorporation of PEI into PMMA fiber matrices was effective in inducing HAp deposition. The present procedure can be applied to the preparation of various hybrid microtubes consisting of biocompatible organic inner layers formed using LbL assemblies and HAp outer layers. Some of these hybrids have potential applications in regenerative medicine or tissue engineering.
引用
收藏
页码:3209 / 3215
页数:7
相关论文
共 46 条
[1]   Layer-by-Layer Assembly of Polysaccharide-Based Polyelectrolyte Multilayers: A Spectroscopic Study of Hydrophilicity, Composition, and Ion Pairing [J].
Almodovar, Jorge ;
Place, Laura W. ;
Gogolski, Jarrod ;
Erickson, Kristin ;
Kipper, Matt J. .
BIOMACROMOLECULES, 2011, 12 (07) :2755-2765
[2]   Forming nanomaterials as layered functional structures toward materials nanoarchitectonics [J].
Ariga, Katsuhiko ;
Ji, Qingmin ;
Hill, Jonathan P. ;
Bando, Yoshio ;
Aono, Masakazu .
NPG ASIA MATERIALS, 2012, 4 :e17-e17
[3]   SPECTRA STRUCTURE CORRELATIONS IN HYDROXY AND FLUORAPATITE [J].
BADDIEL, CB ;
BERRY, EE .
SPECTROCHIMICA ACTA, 1966, 22 (08) :1407-&
[4]   THIN-FILM BEHAVIOR OF POLY(METHYL METHACRYLATES) .2. AN FT-IR STUDY OF LANGMUIR-BLODGETT-FILMS OF ISOTACTIC PMMA [J].
BRINKHUIS, RHG ;
SCHOUTEN, AJ .
MACROMOLECULES, 1991, 24 (07) :1496-1504
[5]   Production of hollow microspheres from nanostructured composite particles [J].
Caruso, F ;
Caruso, RA ;
Möhwald, H .
CHEMISTRY OF MATERIALS, 1999, 11 (11) :3309-3314
[6]   Mineralization of hydroxyapatite in electrospun nanofibrous poly(L-lactic acid) scaffolds [J].
Chen, Jinglu ;
Chu, Benjamin ;
Hsiao, Benjamin S. .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2006, 79A (02) :307-317
[7]   Polymeric multilayer capsules for drug delivery [J].
De Koker, Stefaan ;
Hoogenboom, Richard ;
De Geest, Bruno G. .
CHEMICAL SOCIETY REVIEWS, 2012, 41 (07) :2867-2884
[8]   Fuzzy nanoassemblies: Toward layered polymeric multicomposites [J].
Decher, G .
SCIENCE, 1997, 277 (5330) :1232-1237
[9]  
Donath E, 1998, ANGEW CHEM INT EDIT, V37, P2202, DOI 10.1002/(SICI)1521-3773(19980904)37:16<2201::AID-ANIE2201>3.0.CO
[10]  
2-E