Cancer-derived extracellular vesicles: the 'soil conditioner' in breast cancer metastasis?

被引：49

作者：

Chin, Andrew R. ^{[1
,2
]}

Wang, Shizhen Emily ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Pathol, 9500 Gilman Dr, La Jolla, CA 92093 USA

[2] City Hope Natl Med Ctr, Irell & Manella Grad Sch Biol Sci, Duarte, CA 91010 USA

来源：

CANCER AND METASTASIS REVIEWS | 2016年 / 35卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Breast cancer; Extracellular vesicles; Exosomes; Premetastatic niche; Metastasis; MESENCHYMAL STEM-CELLS; PROMOTE TUMOR-GROWTH; SMALL GTPASE RAB27B; NEUTRAL SPHINGOMYELINASE; PREMETASTATIC NICHE; TISSUE INHIBITOR; EXOSOMES; INVASION; MICROENVIRONMENT; MICROVESICLES;

D O I：

10.1007/s10555-016-9639-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It has been recognized that cancer-associated mortality is more often a result of the disrupted physiological functions in multiple organs following metastatic dissemination of cancer cells, rather than the presence and growth of the primary tumor. Despite advances in our understanding of the events leading to cancer initiation, growth, and acquisition of invasive properties, we are still unable to effectively treat metastatic disease. It is now being accepted that the secretion of extracellular vesicles, such as exosomes from cancer cells, has a profound impact on the initiation and propagation of metastatic breast cancer. These cancer-secreted vesicles differ from other means of cellular communication due to their capability of bulk delivery and organotropism. Here, we provide an overview of the role of extracellular vesicles in breast cancer metastasis and discuss key areas that may facilitate our understanding of metastatic breast cancer to guide our efforts towards providing better therapies.

引用

页码：669 / 676

页数：8

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