DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY DEVELOPMENT OF DOSAGE FORMS CONTAINING A SOLID DISPERSION OF DICLOFENAC

被引：1

作者：

Krasnyuk, I. I., Jr. ^{[1
]}

Ovsyannikova, L. V. ^{[1
]}

Stepanova, O. I. ^{[1
]}

Belyatskaya, A. V. ^{[1
]}

Krasnyuk, I. I. ^{[1
]}

Grikh, V. V. ^{[1
]}

Kosheleva, T. M. ^{[1
]}

Skovpen, Y. V. ^{[2
]}

Kozin, D. A. ^{[1
]}

机构：

[1] IM Sechenov First Moscow State Med Univ Sechenov, Minist Hlth RF, Moscow 119991, Russia

[2] Rancho BioSci, 16955 Via Del Campo,Suite 220, San Diego, CA 92127 USA

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2018年 / 52卷 / 04期

关键词：

diclofenac; solid dispersions; polyethylene glycol-1500; solubility; tablets; bioavailability;

D O I：

10.1007/s11094-018-1821-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Technology development for solid dosage forms with a solid dispersion of diclofenac is a crucial problem in pharmaceutical science and practice. The goal of the work was science-based and experimental technology development for tablets containing a solid dispersion of diclofenac with improved biopharmaceutical indicators as an equivalent to the substance. The obtained granulates and tablets had indicators that met the corresponding standards of the Russian SP XIIIth Ed. Almost 100% of the diclofenac was released from the developed tablets. This was 1.3 times greater than from commercial tablets. The recommended shelf life under these conditions is two years. The proposed technology could not only increase the bioavailability of the slightly soluble non-salt form of diclofenac but also facilitate further development of new medicinal preparations with improved bioavailability.

引用

页码：357 / 360

页数：4

共 7 条

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