WNT and β-catenin signalling:: Diseases and therapies

被引：1534
作者：
Moon, RT [1 ]
Kohn, AD
De Ferrari, GV
Kaykas, A
机构：
[1] Univ Washington, Sch Med, Howard Hughes Med Inst, Dept Pharmacol, Seattle, WA 98195 USA
[2] Univ Washington, Sch Med, Ctr Dev Biol, Seattle, WA 98195 USA
来源：
NATURE REVIEWS GENETICS | 2004年 / 5卷 / 09期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrg1427
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
WNT signalling has been studied primarily in developing embryos, in which cells respond to WNTs in a context-dependent manner through changes in survival and proliferation, cell fate and movement. But WNTs also have important functions in adults, and aberrant signalling by WNT pathways is linked to a range of diseases, most notably cancer. What is the full range of diseases that involve WNT pathways? Can inhibition of WNT signalling form the basis of an effective therapy for some cancers? Could activation of WNT signalling provide new therapies for other clinical conditions? Finally, on the basis of recent experiments, might WNTs normally participate in self-renewal, proliferation or differentiation of stem cells? If so, altering WNT signalling might be beneficial to the use of stem cells for therapeutic means.
引用
收藏
页码：689 / 699
页数：11
相关论文
共 114 条
  • [31] LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:: Arrows point the way
    He, X
    Semenov, M
    Tamai, K
    Zeng, X
    [J]. DEVELOPMENT, 2004, 131 (08): : 1663 - 1677
  • [32] Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells
    Hori, Y
    Rulifson, IC
    Tsai, BC
    Heit, JJ
    Cahoy, JD
    Kim, SK
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (25) : 16105 - 16110
  • [33] New aspects of Wnt signaling pathways in higher vertebrates
    Huelsken, J
    Birchmeier, W
    [J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 2001, 11 (05) : 547 - 553
  • [34] Linkage of a gene causing high bone mass to human chromosome 11 (11q12-13)
    Johnson, ML
    Gong, GD
    Kimberling, W
    Recker, SM
    Kimmel, DB
    Recker, RR
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 1997, 60 (06) : 1326 - 1332
  • [35] Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/β-catenin synergy
    Jordan, BK
    Shen, JHC
    Olaso, R
    Ingraham, HA
    Vilain, E
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (19) : 10866 - 10871
  • [36] Lymphoid enhancer factor-1 and β-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter
    Kahler, RA
    Westendorf, JJ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (14) : 11937 - 11944
  • [37] Presenilin couples the paired phosphorylation of β-catenin independent of axin:: Implications for β-catenin activation in tumorigenesis
    Kang, DE
    Soriano, S
    Xia, XF
    Eberhart, CG
    De Strooper, B
    Zheng, H
    Koo, EH
    [J]. CELL, 2002, 110 (06) : 751 - 762
  • [38] The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia
    Katsu, T
    Ujike, H
    Nakano, T
    Tanaka, Y
    Nomura, A
    Nakata, K
    Takaki, M
    Sakai, A
    Uchida, N
    Imamura, T
    Kuroda, S
    [J]. NEUROSCIENCE LETTERS, 2003, 353 (01) : 53 - 56
  • [39] Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization
    Kaykas, A
    Yang-Snyder, J
    Héroux, M
    Shah, KV
    Bouvier, M
    Moon, RT
    [J]. NATURE CELL BIOLOGY, 2004, 6 (01) : 52 - U13
  • [40] Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signaling
    Kielman, MF
    Rindapää, M
    Gaspar, C
    van Poppel, N
    Breukel, C
    van Leeuwen, S
    Taketo, MM
    Roberts, S
    Smits, R
    Fodde, R
    [J]. NATURE GENETICS, 2002, 32 (04) : 594 - 605
12345678910