Innovation by Evolution: Bringing New Chemistry to Life (Nobel Lecture)

被引:280
作者
Arnold, Frances H. [1 ]
机构
[1] CALTECH, Pasadena, CA 91125 USA
关键词
biocatalysis; enzymes; directed evolution; synthetic methods; protein engineering; C-H AMINATION; DIRECTED EVOLUTION; SUBTILISIN-E; RANDOM MUTAGENESIS; IN-VITRO; ENZYME; CYCLOPROPANATION; PROMISCUITY;
D O I
10.1002/anie.201907729
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:14420 / 14426
页数:7
相关论文
共 38 条
[1]  
[Anonymous], 2018, ANGEW CHEM
[2]  
[Anonymous], LIB BABEL
[3]  
[Anonymous], 1993, The Origins of Order
[4]  
Arnold F.H., 2011, Microbe Magazine, V6, P316, DOI [DOI 10.1128/MICROBE.6.316.1, 10.1128/microbe.6.316.1]
[5]   Directed Evolution: Bringing New Chemistry to Life [J].
Arnold, Frances H. .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 57 (16) :4143-4148
[6]  
Babbitt PC, 2001, ADV PROTEIN CHEM, V55, P1, DOI 10.1016/S0065-3233(01)55001-9
[7]  
Bajaj P., 2016, Angew Chemie Int Ed, V128, P16344, DOI [DOI 10.1002/ANGE.201608680, 10.1002/ange.201608680]
[8]   Gram-Scale Synthesis of Chiral Cyclopropane-Containing Drugs and Drug Precursors with Engineered Myoglobin Catalysts Featuring Complementary Stereoselectivity [J].
Bajaj, Priyanka ;
Sreenilayam, Gopeekrishnan ;
Tyagi, Vikas ;
Fasan, Rudi .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 55 (52) :16110-16114
[9]   DIRECTED EVOLUTION OF AN RNA ENZYME [J].
BEAUDRY, AA ;
JOYCE, GF .
SCIENCE, 1992, 257 (5070) :635-641
[10]   Engineering the third wave of biocatalysis [J].
Bornscheuer, U. T. ;
Huisman, G. W. ;
Kazlauskas, R. J. ;
Lutz, S. ;
Moore, J. C. ;
Robins, K. .
NATURE, 2012, 485 (7397) :185-194