Controlling fibroblast adhesion and proliferation by 1D Al2O3 nanostructures

被引：1

作者：

Aktas, Oral Cenk ^{[1
,2
]}

Metzger, Wolfgang ^{[3
]}

Mees, Lisa ^{[3
]}

Martinez, Marina Miro ^{[4
]}

Haidar, Ayman ^{[2
]}

Oberringer, Martin ^{[3
]}

Wennemuth, Gunther ^{[5
]}

Puetz, Norbert ^{[6
]}

Ghori, Muhammad Zubair ^{[1
]}

Pohlemann, Tim ^{[3
]}

Veith, Michael ^{[4
]}

机构：

[1] Christian Albrechts Univ Kiel, Inst Mat Sci, D-24143 Kiel, Germany

[2] Saarland Univ, Dept Paediat Cardiol, D-66421 Homburg, Germany

[3] Saarland Univ, Dept Trauma Hand & Reconstruct Surg, D-66421 Homburg, Germany

[4] INM Leibniz Inst New Mat, Campus D2 2, D-66123 Saarbrucken, Germany

[5] Univ Clin Essen, Dept Anat, D-45147 Essen, Germany

[6] Saarland Univ, Dept Anat & Cell Biol, D-66421 Homburg, Germany

来源：

IET NANOBIOTECHNOLOGY | 2019年 / 13卷 / 06期

关键词：

biomechanics; adhesion; surface chemistry; biomedical materials; cellular biophysics; surface topography; nanostructured materials; alumina; nanomedicine; fibrotic encapsulation; medical devices; human fibroblasts; cell size; cell number; well-defined actin fibres; focal adhesions; distribution density; fibroblast adhesion; 1D nanostructures; distribution densities; fibroblast proliferation; fibroblast-surface interaction; one-dimensional aluminium oxide nanostructures; Al2O3; SURFACE; NANOTOPOGRAPHY; TOPOGRAPHY;

D O I：

10.1049/iet-nbt.2018.5088

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The fibrotic encapsulation, which is mainly accompanied by an excessive proliferation of fibroblasts, is an undesired phenomenon after the implantation of various medical devices. Beside the surface chemistry, the topography plays also a major role in the fibroblast-surface interaction. In the present study, one-dimensional aluminium oxide (1D Al2O3) nanostructures with different distribution densities were prepared to reveal the response of human fibroblasts to the surface topography. The cell size, the cell number and the ability to form well-defined actin fibres and focal adhesions were significantly impaired with increasing distribution density of the 1D Al2O3 nanostructures on the substratum.

引用

页码：621 / 625

页数：5

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