Systematic review and meta-analysis of global birth prevalence of clubfoot: a study protocol

被引：43

作者：

Ansar, Adnan ^{[1
]}

Rahman, Ahmed Ehsanur ^{[1
]}

Romero, Lorena ^{[2
]}

Haider, Mohammad Rifat ^{[3
,4
]}

Rahman, Mohammad Masudur ^{[1
]}

Moinuddin, Md ^{[1
]}

Siddique, Md Abu Bakkar ^{[1
]}

Al Mamun, Md ^{[5
]}

Mazumder, Tapas ^{[1
]}

Pirani, Shafique Pyarali ^{[6
]}

Mathias, Richard Gordon ^{[7
]}

El Arifeen, Shams ^{[1
]}

Hoque, Dewan Md Emdadul ^{[1
]}

机构：

[1] Int Ctr Diarrhoeal Dis Res, Maternal & Child Hlth Div, Dhaka, Bangladesh

[2] Ian Potter Lib, Melbourne, Vic, Australia

[3] Univ South Carolina, Arnold Sch Publ Hlth, Dept Hlth Serv Policy & Management, Columbia, SC USA

[4] Jahangirnagar Univ, Dept Publ Hlth & Informat, Dhaka, Bangladesh

[5] Int Ctr Diarrhoeal Dis Res, Lib & Informat Serv Sect, Dhaka, Bangladesh

[6] Univ British Columbia, Fac Med, Dept Orthopaed, Vancouver, BC, Canada

[7] Univ British Columbia, Fac Med, Sch Populat & Publ Hlth, Vancouver, BC, Canada

来源：

BMJ OPEN | 2018年 / 8卷 / 03期

关键词：

MIDDLE-INCOME COUNTRIES; EPIDEMIOLOGY;

D O I：

10.1136/bmjopen-2017-019246

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction Clubfoot is a common congenital birth defect, with an average prevalence of approximately 1 per 1000 live births, although this rate is reported to vary among different countries around the world. If it remains untreated, clubfoot causes permanent disability, limits educational and employment opportunities, and personal growth. The aim of this systematic review and meta-analysis is to estimate the global birth prevalence of congenital clubfoot. Methods and analysis Electronic databases including MEDLINE, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Embase, Global Health, Latin American & Caribben Health Science Literature (LILACS), Maternity and Infant Care, Web of Science, Scopus and Google Scholar will be searched for observational studies based on predefined criteria and only in English language from inception of database in 1946 to 10 November 2017. A standard data extraction form will be used to extract relevant information from included studies. The Joanna Briggs Institute appraisal checklist will be used to assess the overall quality of studies reporting prevalence. All included studies will he assessed for risk of bias using a tool developed specifically for prevalence studies. Forest plots will he created to understand the overall random effects of pooled estimates with 95% Cls. An IZ test will be done for heterogeneity of the results (P>0.05), and to identify the source of heterogeneity across studies, subgroup or meta-regression will be used to assess the contribution of each variable to the overall heterogeneity. A funnel plot will be used to identify reporting bias, and sensitivity analysis will be used to assess the impact of methodological quality, study design, sample size and the impact of missing data. Ethics and dissemination This review will be conducted completely based on published data, so approval from an ethics committee or written consent will not he required. The results will be disseminated through a peer-reviewed publication and relevant conference presentations.

引用

页数：7

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