Molecular basis for enhanced activity of posaconazole against Absidia corymbifera and Rhizopus oryzae

被引：20

作者：

Chau, Andrew S. ^{[1
]}

Chen, Guodong ^{[1
]}

McNicholas, Paul M. ^{[1
]}

Mann, Paul A. ^{[1
]}

机构：

[1] Schering Plough Res Inst, Kenilworth, NJ 07033 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 11期

关键词：

D O I：

10.1128/AAC.00747-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Posaconazole and itraconazole were more potent inhibitors of ergosterol synthesis, in both intact cells and cell extracts from Absidia corymbifera and Rhizopus oryzae, than voriconazole and fluconazole. Similarly, expression of CYP51 from R. oryzae in Saccharomyces cerevisiae significantly increased resistance to fluconazole and voriconazole but not to posaconazole and itraconazole.

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页码：3917 / 3919

页数：3

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