Apotirucallane protolimonoids from the Chinese mangrove Xylocarpus granatum Koenig

被引：19

作者：

Zhou, Zhen-Fang ^{[1
]}

Taglialatela-Scafati, Orazio ^{[2
]}

Liu, Hai-Li ^{[1
]}

Gu, Yu-Cheng ^{[3
]}

Kong, Ling-Yi ^{[4
]}

Guo, Yue-Wei ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

[2] Univ Naples Federico II, Dipartimento Farm, I-80131 Naples, Italy

[3] Syngenta Jealotts Hill Int Res Ctr, Guildford RG42 6EY, Berks, England

[4] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Peoples R China

来源：

FITOTERAPIA | 2014年 / 97卷

关键词：

Xylocarpus granatum; Protolimonoid; Apotirucallane; Cytotoxicity; LIMONOIDS;

D O I：

10.1016/j.fitote.2014.06.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of previously unreported compounds including seven new apotirucallane protolimonoids, xylogranatumines A-G (1-7), were isolated together with three known analogues (8-10) from the twigs and leaves of the Chinese mangrove, Xylocarpus granatum. The structures of these new compounds were elucidated by extensive spectroscopic analysis including 1D and 2D NMR and high-resolution electrospray ionization mass spectrometry (HRESIMS) and by comparison with those of related known compounds in the literature. Xylogranatumine F (6) exhibited cytotoxic activity against A549 tumor cell in vitro. (c) 2014 Elsevier B.V. All rights reserved.

引用

页码：192 / 197

页数：6