Apotirucallane protolimonoids from the Chinese mangrove Xylocarpus granatum Koenig

被引：19
|
作者：
Zhou, Zhen-Fang [1 ]
Taglialatela-Scafati, Orazio [2 ]
Liu, Hai-Li [1 ]
Gu, Yu-Cheng [3 ]
Kong, Ling-Yi [4 ]
Guo, Yue-Wei [1 ]
机构：
[1] Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
[2] Univ Naples Federico II, Dipartimento Farm, I-80131 Naples, Italy
[3] Syngenta Jealotts Hill Int Res Ctr, Guildford RG42 6EY, Berks, England
[4] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Peoples R China
来源：
FITOTERAPIA | 2014年 / 97卷
关键词：
Xylocarpus granatum; Protolimonoid; Apotirucallane; Cytotoxicity; LIMONOIDS;
D O I：
10.1016/j.fitote.2014.06.009
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of previously unreported compounds including seven new apotirucallane protolimonoids, xylogranatumines A-G (1-7), were isolated together with three known analogues (8-10) from the twigs and leaves of the Chinese mangrove, Xylocarpus granatum. The structures of these new compounds were elucidated by extensive spectroscopic analysis including 1D and 2D NMR and high-resolution electrospray ionization mass spectrometry (HRESIMS) and by comparison with those of related known compounds in the literature. Xylogranatumine F (6) exhibited cytotoxic activity against A549 tumor cell in vitro. (c) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：192 / 197
页数：6
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