Temperament and character in remitted and symptomatic patients with schizophrenia: Modulation by the COMT Val158Met genotype

被引：6

作者：

Hori, Hiroaki ^{[1
]}

Fujii, Takashi ^{[1
]}

Yamamoto, Noriko ^{[1
]}

Teraishi, Toshiya ^{[1
]}

Ota, Miho ^{[1
]}

Matsuo, Junko ^{[1
]}

Kinoshita, Yukiko ^{[1
]}

Ishida, Ikki ^{[1
]}

Hattori, Kotaro ^{[1
]}

Okazaki, Mitsutoshi ^{[2
]}

Arima, Kunimasa ^{[2
]}

Kunugi, Hiroshi ^{[1
]}

机构：

[1] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Mental Disorder Res, Kodaira, Tokyo 1878502, Japan

[2] Natl Ctr Neurol & Psychiat, Natl Ctr Hosp, Dept Psychiat, Tokyo 1878551, Japan

来源：

JOURNAL OF PSYCHIATRIC RESEARCH | 2014年 / 56卷

关键词：

Schizophrenia; Temperament; Character; Remission; COMT Val158Met polymorphism; CATECHOL-O-METHYLTRANSFERASE; PERSONALITY-TRAITS; NORMATIVE DATA; FUNCTIONAL POLYMORPHISM; GENETIC-VARIATION; NOVELTY SEEKING; MESSENGER-RNA; INVENTORY TCI; ASSOCIATION; REMISSION;

D O I：

10.1016/j.jpsychires.2014.05.006

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

While research on remission in schizophrenia has gained attention, personality characteristics associated with remission in schizophrenia have been under-studied. A functional valine-to-methionine (Val158Met) polymorphism in the catechol-O-methyltransferase (COMT) gene is shown to modify clinical presentation of schizophrenia despite weak or no association with the disorder itself. Studies also report that this polymorphism can affect personality traits. We aimed to examine personality traits of remitted patients with schizophrenia as compared to symptomatic patients and healthy controls and to investigate whether the COMT Val158Met polymorphism influences their personality. Scores on the Temperament and Character Inventory were compared between 34 remitted outpatients with schizophrenia, age- and sex-matched 72 symptomatic outpatients with schizophrenia, and matched 247 healthy individuals. The effect-of COMT Val158Met polymorphism on personality was examined in each group. The analysis of covariance, controlling for confounding variables, revealed that compared to healthy controls, symptomatic patients exhibited a pervasively altered personality profile whereas remitted patients showed alterations in more limited personality dimensions and demonstrated normal levels of novelty-seeking, reward dependence and cooperativeness. The two-way analysis of covariance, with genotype and sex as between-subject factors and confounders as covariates, revealed that Met carriers demonstrated significantly lower reward dependence and cooperativeness than Val homozygotes in symptomatic patients; while no significant genotype effect was found in remitted patients or in healthy individuals. These findings indicate that remitted patients with schizophrenia have a relatively adaptive personality profile compared to symptomatic patients. The COMT Val158Met polymorphism might have a modulating effect on the relationship between personality and remission. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：82 / 89

页数：8

共 89 条

[31] Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia:: Meta-analysis of case-control and family-based studies [J].