Corneal neovascularization

被引：120

作者：

Nicholas, Matthew P. ^{[1
,2
]}

Mysore, Naveen ^{[1
]}

机构：

[1] Univ Rochester, Med Ctr, Flaum Eye Inst, 210 Crittenden Blvd, Rochester, NY 14642 USA

[2] Cleveland Clin, Cole Eye Inst, 9500 Euclid Ave 1-13, Cleveland, OH 44106 USA

来源：

EXPERIMENTAL EYE RESEARCH | 2021年 / 202卷

关键词：

Corneal neovascularization; Vascular endothelial growth factor (VEGF); Angiogenesis; ENDOTHELIAL-GROWTH-FACTOR; COHERENCE TOMOGRAPHY ANGIOGRAPHY; STEM-CELL DEFICIENCY; FACTOR VEGF; AUTOCRINE MECHANISM; TOPICAL BEVACIZUMAB; TISSUE INHIBITOR; GRAFT FAILURE; BLOOD-VESSEL; MITOMYCIN-C;

D O I：

10.1016/j.exer.2020.108363

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The optical clarity of the cornea is essential for maintaining good visual acuity. Corneal neovascularization, which is a major cause of vision loss worldwide, leads to corneal opacification and often contributes to a cycle of chronic inflammation. While numerous factors prevent angiogenesis within the cornea, infection, inflammation, hypoxia, trauma, corneal degeneration, and corneal transplantation can all disrupt these homeostatic safeguards to promote neovascularization. Here, we summarize its etiopathogenesis and discuss the molecular biology of angiogenesis within the cornea. We then review the clinical assessment and diagnostic evaluation of corneal neovascularization. Finally, we describe current and emerging therapies.

引用

页数：13

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