GDF11 expression in the adult rat central nervous system

被引：24
|
作者：
Hayashi, Yutaro [1 ,2 ]
Mikawa, Sumiko [2 ]
Masumoto, Kazuma [1 ]
Katou, Fuminori [1 ]
Sato, Kohji [2 ]
机构：
[1] Hamamatsu Univ Sch Med, Dept Dent & Oral & Maxillofacial Surg, Higashi Ku, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan
[2] Hamamatsu Univ Sch Med, Dept Organ & Tissue Anat, Higashi Ku, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan
来源：
JOURNAL OF CHEMICAL NEUROANATOMY | 2018年 / 89卷
关键词：
GDF11; Axon; Neuropil; Immunohistochemistry; BRAIN; DIFFERENTIATION; PLASTICITY; NUMBER;
D O I：
10.1016/j.jchemneu.2018.02.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP11), is a member of the transforming growth factor beta (TGF-beta) superfamily. Although GDF11 plays pivotal roles during development, including anterior/posterior patterning, formation of the kidney, stomach, spleen and endocrine pancreas, little information is available for GDF11 expression in the adult central nervous system (CNS). We, thus, investigated GDF11 expression in the adult rat CNS using immunohistochemistry. GDF11 was intensely expressed in most neurons and their axons. Furthermore, we found that astrocytes and ependymal cells also express GDF11 protein. These data indicate that GDF11 is widely expressed throughout the adult CNS, and its abundant expression in the adult brain strongly supports the idea that GDF11 plays important roles in the adult brain.
引用
收藏
页码：21 / 36
页数：31
相关论文
共 50 条
  • [31] Neuronal GDNF expression in the adult rat nervous system identified by in situ hybridization
    Pochon, NAM
    Menoud, A
    Tseng, JL
    Zurn, AD
    Aebischer, P
    EUROPEAN JOURNAL OF NEUROSCIENCE, 1997, 9 (03) : 463 - 471
  • [32] Prolyl endopeptidase mRNA expression in the central nervous system during rat development
    Agirregoitia, N.
    Bizet, P.
    Agirregoitia, E.
    Boutelet, I.
    Peralta, L.
    Vaudry, H.
    Jegou, S.
    JOURNAL OF CHEMICAL NEUROANATOMY, 2010, 40 (01) : 53 - 62
  • [33] Adult neurogenesis in the mammalian central nervous system
    Ming, GL
    Song, HJ
    ANNUAL REVIEW OF NEUROSCIENCE, 2005, 28 : 223 - 250
  • [34] Sox2 in the adult rat sensory nervous system
    Kioke, Taro
    Wakabayashi, Taketoshi
    Mori, Tetsuji
    Takamori, Yasuharu
    Hirahara, Yukie
    Yamada, Hisao
    HISTOCHEMISTRY AND CELL BIOLOGY, 2014, 141 (03) : 301 - 309
  • [35] Developmental expression of RFamide-related peptides in the rat central nervous system
    Yano, T
    Iijima, N
    Hinuma, S
    Tanaka, M
    Ibata, Y
    DEVELOPMENTAL BRAIN RESEARCH, 2004, 152 (02): : 109 - 120
  • [36] Ret expression in the central nervous system
    Hagihara, N
    Fukuyama, K
    Tabuchi, K
    NEUROPATHOLOGY, 1998, 18 (04) : 391 - 397
  • [37] Expression of factor X in both the rat brain and cells of the central nervous system
    Shikamoto, Y
    Morita, T
    FEBS LETTERS, 1999, 463 (03) : 387 - 389
  • [38] EXPRESSION OF TRK RECEPTORS IN THE DEVELOPING AND ADULT HUMAN CENTRAL AND PERIPHERAL NERVOUS-SYSTEM
    MURAGAKI, Y
    TIMOTHY, N
    LEIGHT, S
    HEMPSTEAD, BL
    CHAO, MV
    TROJANOWSKI, JQ
    LEE, VMY
    JOURNAL OF COMPARATIVE NEUROLOGY, 1995, 356 (03) : 387 - 397
  • [39] Systemic GDF11 attenuates depression-like phenotype in aged mice via stimulation of neuronal autophagy
    Moigneu, Carine
    Abdellaoui, Soumia
    Ramos-Brossier, Mariana
    Pfaffenseller, Bianca
    Wollenhaupt-Aguiar, Bianca
    Cardoso, Taiane de Azevedo
    Chiche, Aurelie
    Kuperwasser, Nicolas
    da Silva, Ricardo Azevedo
    Moreira, Fernanda Pedrotti
    Li, Han
    Oury, Franck
    Kapczinski, Flavio
    Lledo, Pierre-Marie
    Katsimpardi, Lida
    NATURE AGING, 2023, 3 (02): : 213 - +
  • [40] Distribution of Satb1 in the central nervous system of adult mice
    Huang, Ying
    Zhang, Lei
    Song, Ning-Ning
    Hu, Ze-Lan
    Chen, Jia-Yin
    Ding, Yu-Qiang
    NEUROSCIENCE RESEARCH, 2011, 71 (01) : 12 - 21
12345