Influence of autophagy on the efficacy of radiotherapy

被引：91
作者：
Tam, Shing Yau [1 ]
Wu, Vincent Wing Cheung [1 ]
Law, Helen Ka Wai [1 ]
机构：
[1] Hong Kong Polytech Univ, Fac Hlth & Social Sci, Dept Hlth Technol & Informat, Hong Kong, Peoples R China
来源：
RADIATION ONCOLOGY | 2017年 / 12卷
关键词：
Autophagy; Radiotherapy; Signalling pathway; Radiotherapy efficacy; Radiosensitivity; Cancer Cell lines; RADIATION-INDUCED AUTOPHAGY; CANCER-CELLS; PROSTATE-CANCER; INHIBITION; PATHWAY; RAPAMYCIN; RADIOSENSITIZATION; ACTIVATION; SENESCENCE; INDUCTION;
D O I：
10.1186/s13014-017-0795-y
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Autophagy is an important catabolic process in which cells digest and recycle their own cytoplasmic contents for maintaining cellular homeostasis. Interestingly, autophagy could play both pro-death and pro-survival roles in influencing the development of cancer via various signal pathways. As radiotherapy is one of the main treatment modalities for cancer, we reviewed the effect of autophagy modulations on radiosensitivity and radiotherapy efficacy in various cancer types. The future development of autophagy modifications for improving radiotherapy efficacy and cancer prognosis will also be discussed.
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页数：10
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