Influence of autophagy on the efficacy of radiotherapy

被引：84

作者：

Tam, Shing Yau ^{[1
]}

Wu, Vincent Wing Cheung ^{[1
]}

Law, Helen Ka Wai ^{[1
]}

机构：

[1] Hong Kong Polytech Univ, Fac Hlth & Social Sci, Dept Hlth Technol & Informat, Hong Kong, Peoples R China

来源：

RADIATION ONCOLOGY | 2017年 / 12卷

关键词：

Autophagy; Radiotherapy; Signalling pathway; Radiotherapy efficacy; Radiosensitivity; Cancer Cell lines; RADIATION-INDUCED AUTOPHAGY; CANCER-CELLS; PROSTATE-CANCER; INHIBITION; PATHWAY; RAPAMYCIN; RADIOSENSITIZATION; ACTIVATION; SENESCENCE; INDUCTION;

D O I：

10.1186/s13014-017-0795-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Autophagy is an important catabolic process in which cells digest and recycle their own cytoplasmic contents for maintaining cellular homeostasis. Interestingly, autophagy could play both pro-death and pro-survival roles in influencing the development of cancer via various signal pathways. As radiotherapy is one of the main treatment modalities for cancer, we reviewed the effect of autophagy modulations on radiosensitivity and radiotherapy efficacy in various cancer types. The future development of autophagy modifications for improving radiotherapy efficacy and cancer prognosis will also be discussed.

引用

页数：10

共 38 条

[1] Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21
Aita, VM
Liang, XH
Murty, VVVS
Pincus, DL
Yu, WP
Cayanis, E
Kalachikov, S
Gilliam, TC
Levine, B
[J]. GENOMICS, 1999, 59 (01) : 59 - 65
[2] Targeting the Akt/mammalian target of rapamycin pathway for radiosensitization of breast cancer
Albert, Jeffrey M.
Kim, Kwang Woon
Cao, Carolyn
Lu, Bo
[J]. MOLECULAR CANCER THERAPEUTICS, 2006, 5 (05) : 1183 - 1189
[3] Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy
Apel, Anja
Herr, Ingrid
Schwarz, Heinz
Rodemann, H. Peter
Mayer, Andreas
[J]. CANCER RESEARCH, 2008, 68 (05) : 1485 - 1494
[4] Role of BNIP3 in proliferation and hypoxia-induced autophagy: implications for personalized cancer therapies
Azad, Meghan B.
Gibson, Spencer B.
[J]. TOWARD PERSONALIZED MEDICINE FOR CANCER, 2010, 1210 : 8 - 16
[5] Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells
Cao, Carolyn
Subhawong, Ty
Albert, Jeffrey M.
Kim, Kwang Woon
Geng, Ling
Sekhar, Konjeti R.
Gi, Young Jin
Lu, Bo
[J]. CANCER RESEARCH, 2006, 66 (20) : 10040 - 10047
[6] Synergistic antitumor effects of radiation and proteasome inhibitor treatment in pancreatic cancer through the induction of autophagy and the downregulation of TRAF6
Chiu, Hui-Wen
Lin, Shu-Wen
Lin, Li-Ching
Hsu, Yung-Ho
Lin, Yuh-Feng
Ho, Sheng-Yow
Wu, Yuan-Hua
Wang, Ying-Jan
[J]. CANCER LETTERS, 2015, 365 (02) : 229 - 239
[7] Inhibition of MTOR Disrupts Autophagic Flux in Podocytes
Cina, Davide P.
Onay, Tuncer
Paltoo, Aarti
Li, Chengjin
Maezawa, Yoshiro
De Arteaga, Javier
Jurisicova, Andrea
Quaggin, Susan E.
[J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2012, 23 (03): : 412 - 420
[8] Inhibition of the DNA-dependent protein kinase catalytic subunit radiosensitizes malignant gliorna cells by inducing autophagy
Daido, S
Yamamoto, A
Fujiwara, K
Sawaya, R
Kondo, S
Kondo, Y
[J]. CANCER RESEARCH, 2005, 65 (10) : 4368 - 4375
[9] Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
Ferlay, Jacques
Soerjomataram, Isabelle
Dikshit, Rajesh
Eser, Sultan
Mathers, Colin
Rebelo, Marise
Parkin, Donald Maxwell
Forman, David
Bray, Freddie
[J]. INTERNATIONAL JOURNAL OF CANCER, 2015, 136 (05) : E359 - E386
[10] Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma
Inoue, Daisuke
Suzuki, Takashi
Mitsuishi, Yoichiro
Miki, Yasuhiro
Suzuki, Satoshi
Sugawara, Shunichi
Watanabe, Mika
Sakurada, Akira
Endo, Chiaki
Uruno, Akira
Sasano, Hironobu
Nakagawa, Takayuki
Satoh, Kennichi
Tanaka, Nobuyuki
Kubo, Hiroshi
Motohashi, Hozumi
Yamamoto, Masayuki
[J]. CANCER SCIENCE, 2012, 103 (04) : 760 - 766

← 1 2 3 4 →