Application of Privileged Molecular Framework of 7-Fluoro-1,4-benzodiazepin-2-one-5-methylcarboxylate to the Synthesis of Its 1-and 5-Disubstituted Analogs of Medicinal Interest

Synthetic potential of the privileged molecular framework of 7-fluoro-1,4-benzodiazepin-2-one containing a methyl carboxylate substituent at its 5-position was exploited to develop efficient protocols to the synthesis of several novel 5-(1,3,4)oxadiazole ring incorporated analogs of medicinal interest, appended with the Mannich's base motifs at the nitrogen atom in its seven-membered ring.