Anti-inflammatory amide alkaloids from the stems of Clausena emarginata

被引：12
作者：
Xia, Hong-Min [1 ,2 ]
Li, Chuang-Jun [1 ,2 ]
Yang, Jing-Zhi [1 ,2 ]
Ma, Jie [1 ,2 ]
Li, Li [1 ,2 ]
Zhang, Dan [1 ,2 ]
Bao, Xiu-Qi [1 ,2 ]
Zhang, Dong-Ming [1 ,2 ]
机构：
[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
[2] Peking Union Med Coll, Beijing 100050, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2014年 / 16卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Clausena emarginata; amide alkaloids; anti-inflammatory;
D O I：
10.1080/10286020.2014.943750
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new amide alkaloids, clauemaramide A (1) and clauemaramide B (2), and three known analogs were isolated from the stems of Clausena emarginata. Their structures were determined on the basis of spectroscopic analyses. The absolute configurations of 1 and 2 were confirmed by CD spectroscopy. Compound 3 showed moderate inhibitory effects on LPS-induced NO production (IC50 value = 4.9 mu M).
引用
收藏
页码：971 / 975
页数：5
相关论文
共 9 条
  • [1] Chen S.K., 1997, ZHONGGUO ZHIWU ZHI, V43, P135
  • [2] [Rh2(OCOCF3)4] as an auxiliary chromophore in chiroptical studies on steroidal alcohols
    Frelek, J
    Szczepek, WJ
    [J]. TETRAHEDRON-ASYMMETRY, 1999, 10 (08) : 1507 - 1520
  • [3] PLANTS OF NEW CALEDONIA .45. NEUTRAL PRODUCTS AND ALKALOIDS OF MYRTOPSIS - MACROCARPA, MYRTOPSIS - MYRTORDEA, MYROTPSIS - NOVAE-CALEDONIAE AND MYRTOPSIS-SELLINGII
    HIFNAWY, MS
    VAQUETTE, J
    SEVENET, T
    POUSSET, JL
    CAVE, A
    [J]. PHYTOCHEMISTRY, 1977, 16 (07) : 1035 - 1039
  • [4] Jadwiga F., 2003, CURR ORG CHEM, V7, P1081
  • [5] Chemoenzymatic synthesis of (R)- and (S)-tembamide, aegeline and denopamine by a one-pot lipase resolution protocol
    Kamal, A
    Shaik, AA
    Sandbhor, M
    Malik, MS
    [J]. TETRAHEDRON-ASYMMETRY, 2004, 15 (24) : 3939 - 3944
  • [6] Constituents from Limonia crenulata
    Niu, XM
    Li, SH
    Peng, LY
    Lin, ZW
    Rao, GX
    Sun, HD
    [J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2001, 3 (04) : 299 - 311
  • [7] HORTIAMIDE, A NEW TYRAMINE ALKALOID FROM HORTIA-REGIA
    TINTO, WF
    MCLEAN, S
    REYNOLDS, WF
    [J]. JOURNAL OF NATURAL PRODUCTS, 1992, 55 (11): : 1676 - 1678
  • [8] A,D-seco-Limonoids from the Stems of Clausena emarginata
    Xia, Hong-Min
    Li, Chuang-Jun
    Yang, Jing-Zhi
    Ma, Jie
    Chen, Xiao-Guang
    Zhang, Dan
    Li, Li
    Zhang, Dong-Ming
    [J]. JOURNAL OF NATURAL PRODUCTS, 2014, 77 (04): : 784 - 791
  • [9] Sesquiterpenes and Alkaloids from the Roots of Alangium chinense
    Zhang, Yan
    Liu, Yun-Bao
    Li, Yong
    Ma, Shuang-Gang
    Li, Li
    Qu, Jing
    Zhang, Dan
    Chen, Xiao-Guang
    Jiang, Jian-Dong
    Yu, Shi-Shan
    [J]. JOURNAL OF NATURAL PRODUCTS, 2013, 76 (06): : 1058 - 1063
1