Advanced proteomic technologies for cancer biomarker discovery

被引：38

作者：

Wong, Sze Chuen Cesar ^{[1
,2
]}

Chan, Charles Ming Lok ^{[1
,2
]}

Ma, Brigette Buig Yue ^{[1
,2
]}

Lam, Money Yan Yee ^{[1
,2
]}

Choi, Gigi Ching Gee ^{[1
,2
]}

Au, Thomas Chi Chuen ^{[1
,2
]}

Chan, Andrew Sai Kit ^{[1
,2
]}

Chan, Anthony Tak Cheung ^{[1
,2
]}

机构：

[1] Chinese Univ Hong Kong, State Key Lab Oncol S China, Sir YK Pao Ctr Canc, Dept Clin Oncol,Hong Kong Canc Inst, Hong Kong, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, State Key Lab Oncol S China, Sir YK Pao Ctr Canc, Dept Clin Oncol,Prince Wales Hosp, Hong Kong, Hong Kong, Peoples R China

来源：

EXPERT REVIEW OF PROTEOMICS | 2009年 / 6卷 / 02期

关键词：

2D difference gel electrophoresis; cancer biomarker; electron transfer dissociation; MALDI imaging mass spectrometry; proteomics; reverse-phase protein array; ELECTRON-TRANSFER DISSOCIATION; IMAGING MASS-SPECTROMETRY; DIFFERENTIAL PROTEIN EXPRESSION; BREAST-CANCER; COLLISIONAL ACTIVATION; GEL-ELECTROPHORESIS; TUMOR-MARKERS; TISSUE; PHASE; IDENTIFICATION;

D O I：

10.1586/EPR.09.1

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Proteomic technologies have experienced major improvements in recent years. Such advances have facilitated the discovery of potential tumor markers with improved sensitivities and specificities for the diagnosis, prognosis and treatment monitoring of cancer patients. This review will focus on four state-of-the-art proteomic technologies, namely 2D difference gel electrophoresis, MALDI imaging mass spectrometry, electron transfer dissociation mass spectrometry and reverse-phase protein array. The major advancements these techniques have brought about and examples of their applications in cancer biomarker discovery will be presented in this review, so that readers can appreciate the immense progress in proteomic technologies from 1997 to 2008. Finally, a summary will be presented that discusses current hurdles faced by proteomic researchers, such as the wide dynamic range of protein abundance, standardization of protocols and validation of cancer biomarkers, and a 5-year view of potential solutions to such problems will be provided.

引用

页码：123 / 134

页数：12

共 83 条

[1] Targeted glycoproteomic identification of biomarkers for human breast carcinoma [J].

Abbott, Karen L. ;

Aoki, Kazuhiro ;

Lim, Jae-Min ;

Porterfield, Mindy ;

Johnson, Rachelle ;

O'Regan, Ruth M. ;

Wells, Lance ;

Tiemeyer, Michael ;

Pierce, Michael .

JOURNAL OF PROTEOME RESEARCH, 2008, 7 (04) :1470-1480

[2] Proteomics of breast cancer - Principles and potential clinical applications [J].

Bertucci, Francois ;

Birnbaum, Daniel ;

Goncalves, Anthony .

MOLECULAR & CELLULAR PROTEOMICS, 2006, 5 (10) :1772-1786

[3] Assessing the dynamic range and peak capacity of nanoflow LC-FAIMS-MS on an ion trap mass spectrometer for proteomics [J].

Canterbury, Jesse D. ;

Yi, Xianhua ;

Hoopmann, Michael R. ;

MacCoss, Michael J. .

ANALYTICAL CHEMISTRY, 2008, 80 (18) :6888-6897

[4] Electron transfer dissociation of N-glycopeptides:: loss of the entire N-glycosylated asparagine side chain [J].

Catalina, M. Isabel ;

Koeleman, Carolien A. M. ;

Deelder, Andre M. ;

Wuhrer, Manfred .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2007, 21 (06) :1053-1061

[5]

Chan CML, 2008, ARCH PATHOL LAB MED, V132, P675, DOI 10.1043/1543-2165(2008)132[675:PCONCC]2.0.CO

[6]

[7] Cyclooxygenase-2 expression in advanced nasopharyngeal carcinoma -: a prognostic evaluation and correlation with hypoxia inducible factor 1α and vascular endothelial growth factor [J].

Chan, Charles M. L. ;

Ma, Brigette B. Y. ;

Hui, Edwin P. ;

Wong, Sze. C. C. ;

Mo, Frankie K. F. ;

Leung, Sing. F. ;

Kam, Michael K. M. ;

Chan, Anthony T. C. .

ORAL ONCOLOGY, 2007, 43 (04) :373-378

[8] New developments in profiling and imaging of proteins from tissue sections by MALDI mass spectrometry [J].

Chaurand, Pierre ;

Norris, Jeremy L. ;

Cornett, D. Shannon ;

Mobley, James A. ;

Caprioli, Richard M. .

JOURNAL OF PROTEOME RESEARCH, 2006, 5 (11) :2889-2900

[9] Differential expression of novel tyrosine kinase substrates during breast cancer development [J].

Chen, Yunhao ;

Choong, Lee-Yee ;

Lin, Qingsong ;

Philp, Robin ;

Wong, Chee-Hong ;

Ang, Boon-Keong ;

Tan, Yee-Ling ;

Loh, Marie-Chiew-Shia ;

Hew, Choy-Leong ;

Shah, Nilesh ;

Druker, Brian J. ;

Chong, Poh-Kuan ;

Lim, Yoon-Pin .

MOLECULAR & CELLULAR PROTEOMICS, 2007, 6 (12) :2072-2087

[10] Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry [J].

Chi, An ;

Huttenhower, Curtis ;

Geer, Lewis Y. ;

Coon, Joshua J. ;

Syka, John E. P. ;

Bai, Dina L. ;

Shabanowitz, Jeffrey ;

Burke, Daniel J. ;

Troyanskaya, Olga G. ;

Hunt, Donald F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (07) :2193-2198

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