Arsenic and atherosclerosis

被引：109
作者：
Simeonova, PP [1 ]
Luster, MI [1 ]
机构：
[1] NIOSH, Tissue Injury Team, Toxicol & Mol Biol Branch, Hlth Effects Lab Div, Morgantown, WV 26505 USA
来源：
TOXICOLOGY AND APPLIED PHARMACOLOGY | 2004年 / 198卷 / 03期
关键词：
arsenic toxicity; cardiovascular toxicity; inflammation; environmental factors; vascular diseases;
D O I：
10.1016/j.taap.2003.10.018
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Epidemiological studies have demonstrated a correlation between environmental or occupational arsenic exposure and a risk of vascular diseases related to atherosclerosis. Studies summarized in this review suggest that arsenic induces endothelial dysfunction, including inflammatory and coagulating activity as well as impairs nitric oxide (NO) balance. This may provide the pathophysiological basis for atherogenic potential of arsenic. Consistent with these data, arsenic accelerates atherosclerosis in apolipoprotein E (ApoE) deficient mice, a model of human atherosclerosis. (C) 2004 Elsevier Inc. All rights reserved.
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收藏
页码：444 / 449
页数：6
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