How Many Cell Types Are in the Kidney and What Do They Do?

被引：96
作者：
Balzer, Michael S. [1 ,2 ]
Rohacs, Tibor [3 ]
Susztak, Katalin [1 ,2 ]
机构：
[1] Univ Penn, Dept Med, Renal Electrolyte & Hypertens Div, Philadelphia, PA 19104 USA
[2] Univ Penn, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA
[3] Rutgers New Jersey Med Sch, Dept Pharmacol Physiol & Neurosci, Newark, NJ USA
来源：
ANNUAL REVIEW OF PHYSIOLOGY | 2022年 / 84卷
基金：
美国国家卫生研究院;
关键词：
TAMM-HORSFALL PROTEIN; FAMILIAL HYPERKALEMIC HYPERTENSION; RENAL INTERCALATED CELLS; AMINO-ACID TRANSPORTERS; THICK ASCENDING LIMB; PROXIMAL TUBULE NACL; KELCH-LIKE; MACULA DENSA; RAT-KIDNEY; GLUCOSE-TRANSPORT;
D O I：
10.1146/annurev-physiol-052521-121841
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The kidney maintains electrolyte, water, and acid-base balance, eliminates foreign and waste compounds, regulates blood pressure, and secretes hormones. There are at least 16 different highly specialized epithelial cell types in the mammalian kidney. The number of specialized endothelial cells, immune cells, and interstitial cell types might even be larger. The concerted interplay between different cell types is critical for kidney function. Traditionally, cells were defined by their function or microscopical morphological appearance. With the advent of new single-cell modalities such as transcriptomics, epigenetics, metabolomics, and proteomics we are entering into a new era of cell type definition. This new technological revolution provides new opportunities to classify cells in the kidney and understand their functions.
引用
收藏
页码：507 / 531
页数：25
相关论文
共 169 条
  • [11] Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD
    Boeger, Carsten A.
    Gorski, Mathias
    Li, Man
    Hoffmann, Michael M.
    Huang, Chunmei
    Yang, Qiong
    Teumer, Alexander
    Krane, Vera
    O'Seaghdha, Conall M.
    Kutalik, Zoltan
    Wichmann, H. -Erich
    Haak, Thomas
    Boes, Eva
    Coassin, Stefan
    Coresh, Josef
    Kollerits, Barbara
    Haun, Margot
    Paulweber, Bernhard
    Koettgen, Anna
    Li, Guo
    Shlipak, Michael G.
    Powe, Neil
    Hwang, Shih-Jen
    Dehghan, Abbas
    Rivadeneira, Fernando
    Uitterlinden, Andre
    Hofman, Albert
    Beckmann, Jacques S.
    Kraemer, Bernhard K.
    Witteman, Jacqueline
    Bochud, Murielle
    Siscovick, David
    Rettig, Rainer
    Kronenberg, Florian
    Wanner, Christoph
    Thadhani, Ravi I.
    Heid, Iris M.
    Fox, Caroline S.
    Kao, W. H.
    [J]. PLOS GENETICS, 2011, 7 (09):
  • [12] Acid-base transport by the renal proximal tubule
    Boron, Walter F.
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2006, 17 (09): : 2368 - 2382
  • [13] NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome
    Boute, N
    Gribouval, O
    Roselli, S
    Benessy, F
    Lee, H
    Fuchshuber, A
    Dahan, K
    Gubler, MC
    Niaudet, P
    Antignac, C
    [J]. NATURE GENETICS, 2000, 24 (04) : 349 - 354
  • [14] Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities
    Boyden, Lynn M.
    Choi, Murim
    Choate, Keith A.
    Nelson-Williams, Carol J.
    Farhi, Anita
    Toka, Hakan R.
    Tikhonova, Irina R.
    Bjornson, Robert
    Mane, Shrikant M.
    Colussi, Giacomo
    Lebel, Marcel
    Gordon, Richard D.
    Semmekrot, Ben A.
    Poujol, Alain
    Valimaki, Matti J.
    De Ferrari, Maria E.
    Sanjad, Sami A.
    Gutkin, Michael
    Karet, Fiona E.
    Tucci, Joseph R.
    Stockigt, Jim R.
    Keppler-Noreuil, Kim M.
    Porter, Craig C.
    Anand, Sudhir K.
    Whiteford, Margo L.
    Davis, Ira D.
    Dewar, Stephanie B.
    Bettinelli, Alberto
    Fadrowski, Jeffrey J.
    Belsha, Craig W.
    Hunley, Tracy E.
    Nelson, Raoul D.
    Trachtman, Howard
    Cole, Trevor R. P.
    Pinsk, Maury
    Bockenhauer, Detlef
    Shenoy, Mohan
    Vaidyanathan, Priya
    Foreman, John W.
    Rasoulpour, Majid
    Thameem, Farook
    Al-Shahrouri, Hania Z.
    Radhakrishnan, Jai
    Gharavi, Ali G.
    Goilav, Beatrice
    Lifton, Richard P.
    [J]. NATURE, 2012, 482 (7383) : 98 - U126
  • [15] Brenner BM, 2008, Brenner & Rector's The Kidney, P91
  • [16] AN H+-ATPASE IN OPPOSITE PLASMA-MEMBRANE DOMAINS IN KIDNEY EPITHELIAL-CELL SUBPOPULATIONS
    BROWN, D
    HIRSCH, S
    GLUCK, S
    [J]. NATURE, 1988, 331 (6157) : 622 - 624
  • [17] FUROSEMIDE EFFECT ON ISOLATED PERFUSED TUBULES
    BURG, M
    STONER, L
    CARDINAL, J
    GREEN, N
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1973, 225 (01): : 119 - 124
  • [18] WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells
    Cai, H.
    Cebotaru, V.
    Wang, J. -H.
    Zhang, X. -M.
    Cebotaru, L.
    Guggino, S. E.
    Guggino, W. B.
    [J]. KIDNEY INTERNATIONAL, 2006, 69 (12) : 2162 - 2170
  • [19] Mechanism of release of urinary Tamm-Horsfall glycoprotein from the kidney GPI-anchored counterpart
    Cavallone, D
    Malagolini, N
    Serafini-Cessi, F
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 280 (01) : 110 - 114
  • [20] Renal intercalated cells are rather energized by a proton than a sodium pump
    Chambrey, Regine
    Kurth, Ingo
    Peti-Peterdi, Janos
    Houillier, Pascal
    Purkerson, Jeffrey M.
    Leviel, Francoise
    Hentschke, Moritz
    Zdebik, Anselm A.
    Schwartz, George J.
    Huebner, Christian A.
    Eladari, Dominique
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (19) : 7928 - 7933
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