Metformin: A Potential Drug to Treat Hyperpigmentation Disorders

被引：8

作者：

Belisle, Elisabeth S. ^{[1
]}

Park, Hee-Young ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Div Grad Med Sci, Dept Dermatol, Boston, MA 02118 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2014年 / 134卷 / 10期

关键词：

PROTEIN-KINASE; PIGMENTATION;

D O I：

10.1038/jid.2014.245

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Hyperpigmentation disorders are generally difficult to treat because of the limited availability of effective therapeutics with minimal side effects. In this issue, Lehraiki et al. report that metformin, an antidiabetic drug, inhibited melanogenesis, in vitro and in vivo, and they suggest that metformin may be used to treat hyperpigmentation disorders. This commentary reviews the molecular mechanisms through which metformin inhibits melanogenesis and examines metformin as a potential drug to treat hyperpigmentation.

引用

页码：2488 / 2491

页数：5

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