Gain of function mutagenesis of the erythromycin polyketide synthase .2. Engineered biosynthesis of eight-membered ring tetraketide lactone

被引：74
作者：
Kao, CM
McPherson, M
McDaniel, RN
Fu, H
Cane, DE
Khosla, C
机构：
[1] STANFORD UNIV,DEPT CHEM ENGN,STANFORD,CA 94305
[2] STANFORD UNIV,DEPT CHEM & BIOCHEM,STANFORD,CA 94305
[3] BROWN UNIV,DEPT CHEM,PROVIDENCE,RI 02912
[4] KOSAN BIOSCI INC,BURLINGAME,CA 94010
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1997年 / 119卷 / 46期
关键词：
D O I：
10.1021/ja972609e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
[No abstract available]
引用
收藏
页码：11339 / 11340
页数：2
相关论文
共 25 条
[1]   A functional chimeric modular polyketide synthase generated via domain replacement [J].
Bedford, D ;
Jacobsen, JR ;
Luo, GL ;
Cane, DE ;
Khosla, C .
CHEMISTRY & BIOLOGY, 1996, 3 (10) :827-831
[2]   REPOSITIONING OF A DOMAIN IN A MODULAR POLYKETIDE SYNTHASE TO PROMOTE SPECIFIC CHAIN CLEAVAGE [J].
CORTES, J ;
WIESMANN, KEH ;
ROBERTS, GA ;
BROWN, MJB ;
STAUNTON, J ;
LEADLAY, PF .
SCIENCE, 1995, 268 (5216) :1487-1489
[3]   ORGANIZATION OF THE ENZYMATIC DOMAINS IN THE MULTIFUNCTIONAL POLYKETIDE SYNTHASE INVOLVED IN ERYTHROMYCIN FORMATION IN SACCHAROPOLYSPORA-ERYTHRAEA [J].
DONADIO, S ;
KATZ, L .
GENE, 1992, 111 (01) :51-60
[4]   AN ERYTHROMYCIN ANALOG PRODUCED BY REPROGRAMMING OF POLYKETIDE SYNTHESIS [J].
DONADIO, S ;
MCALPINE, JB ;
SHELDON, PJ ;
JACKSON, M ;
KATZ, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (15) :7119-7123
[5]   MODULAR ORGANIZATION OF GENES REQUIRED FOR COMPLEX POLYKETIDE BIOSYNTHESIS [J].
DONADIO, S ;
STAVER, MJ ;
MCALPINE, JB ;
SWANSON, SJ ;
KATZ, L .
SCIENCE, 1991, 252 (5006) :675-679
[6]   BIOSYNTHESIS OF THE ERYTHROMYCIN MACROLACTONE AND A RATIONAL APPROACH FOR PRODUCING HYBRID MACROLIDES [J].
DONADIO, S ;
STAVER, MJ ;
MCALPINE, JB ;
SWANSON, SJ ;
KATZ, L .
GENE, 1992, 115 (1-2) :97-103
[7]  
GOKHALE RS, UNPUB
[8]  
Hopwood D.A., 1985, GENETIC MANIPULATION
[9]   RING-CLOSURE REACTIONS OF BIFUNCTIONAL CHAIN MOLECULES [J].
ILLUMINATI, G ;
MANDOLINI, L .
ACCOUNTS OF CHEMICAL RESEARCH, 1981, 14 (04) :95-102
[10]   Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase [J].
Jacobsen, JR ;
Hutchinson, CR ;
Cane, DE ;
Khosla, C .
SCIENCE, 1997, 277 (5324) :367-369
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