Dosing Cefepime for Renal Function Does Not Completely Prevent Neurotoxicity in a Patient With Kidney Transplant

被引：10

作者：

Balderia, Percy Guanzon ^{[1
]}

Chandorkar, Aditya ^{[1
]}

Kim, Yongwoo ^{[2
]}

Patnaik, Soumya ^{[1
]}

Sloan, Joshua ^{[1
]}

Newman, George Charles ^{[2
]}

机构：

[1] Albert Einstein Med Ctr, Dept Med, Philadelphia, PA 19141 USA

[2] Albert Einstein Med Ctr, Dept Neurosensory Sci, Philadelphia, PA 19141 USA

来源：

JOURNAL OF PATIENT SAFETY | 2018年 / 14卷 / 02期

关键词：

encephalopathy; seizures; cefepime; transplants;

D O I：

10.1097/PTS.0000000000000225

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Dosing cefepime for renal function does not completely prevent neurotoxicity in a kidney transplant patient. Cefepime neurotoxicity has been reported primarily among patients with renal insufficiency who received standard doses of the antibiotic. We report a case of nonconvulsive status epilepticus from dose-adjusted cefepime in a kidney transplant patient. The timing of symptoms along with clinical and electroencephalographic improvement after discontinuation of cefepime was critical to the diagnosis. Whether we should adjust the dose of cefepime differently in a patient with transplanted kidney to prevent neurotoxicity is unknown.

引用

页码：e33 / e34

页数：2

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