Indole Alkaloids with Potential Anticancer Activity

被引：49
|
作者：
Xu, Dan [1 ]
Xu, Zhi [1 ]
机构：
[1] Guizhou Univ Tradit Chinese Med, Coll Pharmaceut Sci, Guiyang 550025, Peoples R China
来源：
CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2020年 / 20卷 / 21期
关键词：
Indole alkaloids; Anticancer; Structure-activity relationship; Mechanisms of action; Vinblastine; Vincristine; APOPTOSIS-INDUCING ACTIVITY; BISINDOLE ALKALOIDS; HCT116; COLON; CANCER; FRUITS; CYTOTOXICITY; DERIVATIVES; CARCINOMA; CELLS; PROLIFERATION;
D O I：
10.2174/1568026620666200622150325
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Indole alkaloids, which are abundant in nature, are a significant source of pharmacologically active compounds. Indole alkaloids have the potential to exert anticancer activity via various antiproliferative mechanisms, and some of them, such as Vinblastine and Vincristinem, have already used in clinics or under clinical evaluations for the treatment of cancers. Therefore, indole alkaloids occupy an important position in the discovery of novel anticancer agents. This review emphasizes the recent development of indole alkaloids as potential anticancer agents, their structure-activity relationship, and mechanisms of action covering the articles published from 2015 to 2020.
引用
收藏
页码：1938 / 1949
页数：12
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