A Tissue Engineering Approach to Metastatic Colon Cancer

被引：14

作者：

Sarvestani, Samaneh Kamali ^{[1
]}

DeHaan, Reece K. ^{[1
,2
]}

Miller, Paula G. ^{[3
,4
]}

Bose, Shree ^{[5
]}

Shen, Xiling ^{[5
]}

Shuler, Michael L. ^{[3
,4
]}

Huang, Emina H. ^{[1
,2
]}

机构：

[1] Case Western Reserve Univ, Dept Canc Biol, Lerner Coll Med, Cleveland Clin, Cleveland, OH 44195 USA

[2] Case Western Reserve Univ, Dept Colon & Rectal Surg, Lerner Coll Med, Cleveland Clin, Cleveland, OH 44195 USA

[3] Cornell Univ, Dept Biomed Engn, Ithaca, NY 14850 USA

[4] Cornell Univ, Dept Chem & Biomol Engn, Ithaca, NY 14850 USA

[5] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA

来源：

ISCIENCE | 2020年 / 23卷 / 11期

关键词：

TIME IMAGING REVEALS; COLORECTAL-CANCER; MOUSE MODELS; IN-VITRO; LIVER METASTASIS; ORTHOTOPIC TRANSPLANTATION; CELL INVASION; TUMOR-GROWTH; PROGRESSION; CHIP;

D O I：

10.1016/j.isci.2020.101719

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Colon cancer remains the third most common cause of cancer in the US, and the third most common cause of cancer death. Worldwide, colon cancer is the second most common cause of cancer and cancer deaths. At least 25% of patients still present with metastatic disease, and at least 25-30% will develop metastatic colon cancer in the course of their disease. While chemotherapy and surgery remain the mainstay of treatment, understanding the fundamental cellular niche and mechanical properties that result in metastases would facilitate both prevention and cure. Advances in biomaterials, novel 3D primary human cells, modelling using microfluidics and the ability to alter the physical environment, now offers a unique opportunity to develop and test impactful treatment.

引用

页数：16

共 117 条

[81] The role of mouse models in colorectal cancer research-The need and the importance of the orthotopic models [J].

Oliveira, Rui C. ;

Abrantes, Ana Margarida ;

Tralhao, Jose Guilherme ;

Botelho, Maria Filomena .

ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2020, 3 (01) :1-8

[82] Regeneration and orthotopic transplantation of a bioartificial lung [J].

Ott, Harald C. ;

Clippinger, Ben ;

Conrad, Claudius ;

Schuetz, Christian ;

Pomerantseva, Irina ;

Ikonomou, Laertis ;

Kotton, Darrell ;

Vacanti, Joseph P. .

NATURE MEDICINE, 2010, 16 (08) :927-U131

[83]

Paget S., LANCET, V1, P571, DOI DOI 10.1016/S0140-6736(00)49915-0

[84] Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps [J].

Park, Juwon ;

Wysocki, Robert W. ;

Amoozgar, Zohreh ;

Maiorino, Laura ;

Fein, Miriam R. ;

Jorns, Julie ;

Schott, Anne F. ;

Kinugasa-Katayama, Yumi ;

Lee, Youngseok ;

Nam Hee Won ;

Nakasone, Elizabeth S. ;

Hearn, Stephen A. ;

Kuettner, Victoria ;

Qiu, Jing ;

Almeida, Ana S. ;

Perurena, Naiara ;

Kessenbrock, Kai ;

Goldberg, Michael S. ;

Egeblad, Mikala .

SCIENCE TRANSLATIONAL MEDICINE, 2016, 8 (361)

[85] Decellularized colorectal cancer matrix as bioactive microenvironment for in vitro 3D cancer research [J].

Piccoli, Martina ;

D'Angelo, Edoardo ;

Crotti, Sara ;

Sensi, Francesca ;

Urbani, Luca ;

Maghin, Edoardo ;

Burns, Alan ;

De Coppi, Paolo ;

Fassan, Matteo ;

Rugge, Massimo ;

Rizzolio, Flavio ;

Giordano, Antonio ;

Pilati, Pierluigi ;

Mammano, Enzo ;

Pucciarelli, Salvatore ;

Agostini, Marco .

JOURNAL OF CELLULAR PHYSIOLOGY, 2018, 233 (08) :5937-5948

[86] Decellularized human colorectal cancer matrices polarize macrophages towards an anti-inflammatory phenotype promoting cancer cell invasion via CCL18 [J].

Pinto, M. L. ;

Rios, E. ;

Silva, A. C. ;

Neves, S. C. ;

Caires, H. R. ;

Pinto, A. T. ;

Duraes, C. ;

Carvalho, F. A. ;

Cardoso, A. P. ;

Santos, N. C. ;

Barrias, C. C. ;

Nascimento, D. S. ;

Pinto-do-O, P. ;

Barbosa, M. A. ;

Carneiro, F. ;

Oliveira, M. J. .

BIOMATERIALS, 2017, 124 :211-224

[87] Mechanisms of Metastasis in Colorectal Cancer and Metastatic Organotropism: Hematogenous versus Peritoneal Spread [J].

Pretzsch, E. ;

Boesch, F. ;

Neumann, J. ;

Ganschow, P. ;

Bazhin, A. ;

Guba, M. ;

Werner, J. ;

Angele, M. .

JOURNAL OF ONCOLOGY, 2019, 2019

[88]

Ptácek V, 2013, SEED AND SEEDLINGS XI, P135

[89] Metastatic Tumor-in-a-Dish, a Novel Multicellular Organoid to Study Lung Colonization and Predict Therapeutic Response [J].

Ramamoorthy, Prabhu ;

Thomas, Sufi Mary ;

Kaushik, Gaurav ;

Subramaniam, Dharmalingam ;

Chastain, Katherine M. ;

Dhar, Animesh ;

Tawfik, Ossama ;

Kasi, Anup ;

Sun, Weijing ;

Ramalingam, Satish ;

Gunewardena, Sumedha ;

Umar, Shahid ;

Mammen, Joshua M. ;

Padhye, Subhash B. ;

Weir, Scott J. ;

Jensen, Roy A. ;

Sittampalam, G. Sitta ;

Anant, Shrikant .

CANCER RESEARCH, 2019, 79 (07) :1681-1695

[90] Surgical implantation of an abdominal imaging window for intravital microscopy [J].

Ritsma, Laila ;

Steller, Ernst J. A. ;

Ellenbroek, Saskia I. J. ;

Kranenburg, Onno ;

Rinkes, Inne H. M. Borel ;

van Rheenen, Jacco .

NATURE PROTOCOLS, 2013, 8 (03) :583-594

← 3 4 5 6 7 8 9 10 11 12 →