Spatiotemporal dynamics of dendritic spines in the living brain

被引：70

作者：

Chen, Chia-Chien ^{[1
]}

Lu, Ju ^{[2
,3
]}

Zuo, Yi ^{[1
]}

机构：

[1] Univ Calif Santa Cruz, Dept Mol Cell & Dev Biol, Santa Cruz, CA 95064 USA

[2] Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA

[3] Stanford Univ, James H Clark Ctr, Stanford, CA 94305 USA

来源：

FRONTIERS IN NEUROANATOMY | 2014年 / 8卷

关键词：

dendritic spine; in vivo; two-photon imaging; experience-dependent plasticity; neural circuit; cerebral cortex; EXPERIENCE-DEPENDENT PLASTICITY; FRAGILE-X-SYNDROME; NEOCORTEX IN-VIVO; STRUCTURAL PLASTICITY; PYRAMIDAL NEURONS; MOUSE MODEL; SYNAPTIC PLASTICITY; VISUAL-CORTEX; SOMATOSENSORY CORTEX; CORTICAL CIRCUITS;

D O I：

10.3389/fnana.2014.00028

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Dendrite spines are ubiquitous postsynaptic sites of most excitatory synapses in the mammalian brain, and thus may serve as structural indicators of functional synapses. Recent works have suggested that neuronal coding of memories may be associated with rapid alterations in spine formation and elimination. Technological advances have enabled researchers to study spine dynamics in vivo during development as well as under various physiological and pathological conditions. We believe that better understanding of the spatiotemporal patterns of spine dynamics will help elucidate the principles of experience-dependent circuit modification and information processing in the living brain.

引用

页数：7

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