Alcohol consumption and risk of atrial fi brillation in asymptomatic healthy adults

BACKGROUND Excessive alcohol consumption is related to atrial fibrillation (AF) development in the general population. OBJECTIVE The purpose of this study was to investigate the effect of alcohol consumption on new-onset AF development in asymptomatic healthy individuals. METHODS Asymptomatic healthy adults (age <75 years; body mass index <30 kg/m(2)) undergoing routine health examinations from 2007 to 2015 were screened. Those with sinus rhythm and without any previously diagnosed medical or surgical illness were recruited for analysis. The primary outcome was new-onset AF. Secondary outcomes were a composite of non-AF cardiac events, including clinically significant tachyor bradyarrhythmias, acute myocardial infarction, heart failure, or cardiac death. RESULTS Among 19,634 individuals (50% male; age 19-74 years), 199 cardiac events were recorded, including new-onset AF (n = 160), acute myocardial infarction (n = 30), and clinically significanttachyor bradyarrhythmia (n =19), during mean follow-up of 7.0 2.8 years. The incidence of new-onset AF was higher in drinkers (hazard ratio [HR] 2.21; 95% confidence interval [CI] 1.55-3.14; P <.001), whereas composite non-AF cardiac events were not correlated to alcohol. There was a dose-dependent increase in the risk of AF according to the amount of alcohol consumed, and the risk increased more abruptly in men than in women. The risk of AF was highest in frequent binge drinkers (HR 3.15; 95% CI 1.98-4.99; P <.001), compared to infrequent light drinkers. CONCLUSION In the asymptomatic healthy population, drinking increases the risk of new-onset AF in a dose-dependent manner, regardless of sex. Frequent binge drinking should be avoided.