Cumulative and after-effects of short and weak coordinated reset stimulation: a modeling study

被引：68

作者：

Hauptmann, C. ^{[1
]}

Tass, P. A. ^{[1
,2
,3
]}

机构：

[1] Forschungszentrum Julich, Inst Neurosci & Biophys 3, Med & Virtual Inst Neuromodulat, D-52425 Julich, Germany

[2] Univ Cologne, Dept Stereotax & Funct Neurosurg, D-50931 Cologne, Germany

[3] Forschungszentrum Julich, Brain Imaging Ctr W, D-52425 Julich, Germany

来源：

JOURNAL OF NEURAL ENGINEERING | 2009年 / 6卷 / 01期

关键词：

DEEP BRAIN-STIMULATION; TIMING-DEPENDENT PLASTICITY; HIGH-FREQUENCY STIMULATION; NIGRA PARS RETICULATA; SUBTHALAMIC NUCLEUS; PARKINSONS-DISEASE; FOLLOW-UP; ELECTRICAL-STIMULATION; SYNAPTIC MODIFICATIONS; BASAL GANGLIA;

D O I：

10.1088/1741-2560/6/1/016004

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We show that the dynamical multistability of a network of bursting subthalamic neurons, caused by synaptic plasticity has a strong impact on the stimulus-response properties when exposed to weak and short desynchronizing stimuli. Intriguingly, such stimuli can reliably shift the network from a stable state with pathological synchrony and connectivity to a stable desynchronized state with down-regulated connectivity. However, unlike in the case of stronger coordinated reset stimulation, after termination of weaker stimulation the network may undergo a transient rebound of synchrony. When the coordinated reset stimulation is even weaker and/or shorter, so that a single stimulation epoch is not effective, the network dynamics and connectivity can still be reshaped in it cumulative manner by repetitive stimulation delivery.

引用

页数：13

共 57 条

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