Temporal regulation of EphA4 in astroglia during murine retinal and optic nerve development

被引：37

作者：

Petros, Timothy J. ^{[1
]}

Williams, Scott E. ^{[1
]}

Mason, Carol A. ^{[1
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, Dept Pathol, Ctr Neurobiol & Behav, New York, NY 10032 USA

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 2006年 / 32卷 / 1-2期

关键词：

EphA4; astrocytes; retina; optic nerve; axon guidance; development;

D O I：

10.1016/j.mcn.2006.02.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Eph receptors and their ephrin ligands play important roles in many aspects of visual system development. In this study, we characterized the spatial and temporal expression pattern of EphA4 in astrocyte precursor cell (APC) and astrocyte populations in the murine retina and optic nerve. EphA4 is expressed by immotile optic disc astrocyte precursor cells (ODAPS), but EphA4 is downregulated as these cells migrate into the retina. Surprisingly, mature astrocytes in the adult retina re-express EphA4. Within the optic nerve, EphA4 is expressed in specialized astrocytes that form a meshwork at the optic nerve head (ONH). Our in vitro and in vivo data indicate that EphA4 is dispensable for retinal ganglion cell (RGC) axon growth and projections through the chiasm. While optic stalk structure, APC proliferation and migration, retinal vascularization, and oligodendrocyte migration appear normal in EphA4 mutants, the expression of EphA4 in APCs and in the astrocyte meshwork at the ONH has implications for optic nerve pathologies. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：49 / 66

页数：18

共 93 条

[81]

Torres MA, 1996, DEVELOPMENT, V122, P3381

[82] Glial cell migration directed by axon guidance cues [J].

Tsai, HH ;

Miller, RH .

TRENDS IN NEUROSCIENCES, 2002, 25 (04) :173-175

[83] The EphA4 receptor tyrosine kinase is necessary for the guidance of nasal retinal ganglion cell axons in vitro [J].

Walkenhorst, J ;

Dütting, D ;

Handwerker, C ;

Huai, JS ;

Tanaka, H ;

Drescher, U .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2000, 16 (04) :365-375

[84]

Wallace VA, 1999, DEVELOPMENT, V126, P2901

[85]

WALTER J, 1987, DEVELOPMENT, V101, P685

[86] Crossed and uncrossed retinal axons respond differently to cells of the optic chiasm midline in vitro [J].

Wang, LC ;

Dani, J ;

Godement, P ;

Marcus, RC ;

Mason, CA .

NEURON, 1995, 15 (06) :1349-1364

[87] RETINAL ASTROCYTES ARE IMMIGRANTS FROM THE OPTIC-NERVE [J].

WATANABE, T ;

RAFF, MC .

NATURE, 1988, 332 (6167) :834-837

[88] Multiple roles of Eph receptors and ephrins in neural development [J].

Wilkinson, DG .

NATURE REVIEWS NEUROSCIENCE, 2001, 2 (03) :155-164

[89] Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm [J].

Williams, SE ;

Mann, F ;

Erskine, L ;

Sakurai, T ;

Wei, SN ;

Rossi, DJ ;

Gale, NW ;

Holt, CE ;

Mason, CA ;

Henkemeyer, M .

NEURON, 2003, 39 (06) :919-935

[90]

Willson CA, 2002, CELL TRANSPLANT, V11, P229

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