Genetic pattern of CYP1A1*2A (T>C) gene in patients with colorectal cancer in South Jakarta - Indonesia

被引：0
作者：
Adhiyanto, Chris [1 ]
Nisa, Hoirun [1 ]
Ardini, Witri [1 ]
Harriyati, Zeti [1 ]
Suryani [1 ]
Amu, Dina Adlina [1 ]
Fajar, Kemal A. L. [1 ]
Poniman, Taslim [1 ]
Saunar, Rofi [1 ]
Aditomo, W. [1 ]
机构：
[1] State Islamic Univ UIN Syarif Hidayatullah, Fac Med & Hlth Sci, Jakarta 15419, Indonesia
来源：
PROCEEDINGS OF THE 1ST INTERNATIONAL INTEGRATIVE CONFERENCE ON HEALTH, LIFE AND SOCIAL SCIENCES (ICHLAS 2017) | 2017年 / 10卷
关键词：
CYP1A1*2A; colorectal cancer; Indonesia; LUNG-CANCER; RACIAL-DIFFERENCES; CIGARETTE-SMOKING; CYP1A1; GENOTYPE; POLYMORPHISMS; RISK; SUSCEPTIBILITY; COLON; MSPI;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The information of relationship between genetics and cancer in Indonesia, especially colon cancer, is still limited. This study aimed to determine the genetic pattern of colon cancer allele in Fatmawati Hospital, Jakarta -Indonesia. We conducted a case-control study of 40 colorectal cancer patients and 133 volunteers as controls. We observed CYP1A1*2A alleles using RFLP-PCR method. Three milliliters of blood was used to isolate DNA. Our observation showed of the genetic patterns CYP1A1*2A with the incidence of colorectal cancer showed 17 patients were variant-type homozygote and 12 patients were heterozygote type. In this research shown the common of genotyping type CYP1A1*2A of colorectal cancer from the patients are a homozygous variant type.
引用
收藏
页码：20 / 22
页数：3
相关论文
共 21 条
  • [1] Abdullah Murdani, 2012, Gastroenterol Hepatol Bed Bench, V5, P71
  • [2] COSMA G, 1993, CANCER EPIDEM BIOMAR, V2, P53
  • [3] GENETIC-LINKAGE OF LUNG CANCER-ASSOCIATED MSPI POLYMORPHISMS WITH AMINO-ACID REPLACEMENT IN THE HEME BINDING REGION OF THE HUMAN CYTOCHROME-P450IA1 GENE
    HAYASHI, S
    WATANABE, J
    NAKACHI, K
    KAWAJIRI, K
    [J]. JOURNAL OF BIOCHEMISTRY, 1991, 110 (03) : 407 - 411
  • [4] Polymorphism of the CYP1A1*2A gene and susceptibility to lung cancer in a Brazilian population
    Honma, Helen Naemi
    de Capitani, Eduardo Mello
    Barbeiro, Aristoteles de Souza
    Costa, Daniel Botelho
    Morcillo, Andre
    Zambon, Lair
    [J]. JORNAL BRASILEIRO DE PNEUMOLOGIA, 2009, 35 (08) : 767 - 772
  • [5] Inoue H, 2000, CANCER RES, V60, P3749
  • [6] Ishibe N., 2009, CANCER EPIDEM BIOMAR, V9, P855
  • [7] CYP1A induction and human risk assessment: An evolving tale of in vitro and in vivo studies
    Ma, Qiang
    Lu, Anthony Y. H.
    [J]. DRUG METABOLISM AND DISPOSITION, 2007, 35 (07) : 1009 - 1016
  • [8] The CYP1A1 genotype may alter the association of meat consumption patterns and preparation with the risk of colorectal cancer in men and women
    Murtaugh, MA
    Sweeney, C
    Ma, KN
    Caan, BJ
    Slattery, ML
    [J]. JOURNAL OF NUTRITION, 2005, 135 (02) : 179 - 186
  • [9] CYP1A1*2A polymorphism as a predictor of clinical outcome in advanced lung cancer patients treated with EGFR-TKI and its combined effects with EGFR intron 1 (CA)n polymorphism
    Nie, Qiang
    Yang, Xue-ning
    An, She-juan
    Zhang, Xu-chao
    Yang, Jin-ji
    Zhong, Wen-zhao
    Liao, Ri-qiang
    Chen, Zhi-hong
    Su, Jian
    Xie, Zhi
    Wu, Yi-long
    [J]. EUROPEAN JOURNAL OF CANCER, 2011, 47 (13) : 1962 - 1970
  • [10] Cigarette smoking, genetic polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study
    Nisa, Hoirun
    Kono, Suminori
    Yin, Guang
    Toyomura, Kengo
    Nagano, Jun
    Mibu, Ryuichi
    Tanaka, Masao
    Kakeji, Yoshihiro
    Maehara, Yoshihiko
    Okamura, Takeshi
    Ikejiri, Koji
    Futami, Kitaroh
    Maekawa, Takafumi
    Yasunami, Yohichi
    Takenaka, Kenji
    Ichimiya, Hitoshi
    Terasaka, Reiji
    [J]. BMC CANCER, 2010, 10
123