A convergent synthesis of Ro24-5913, a novel leukotriene D-4 antagonist

被引：10

作者：

Maehr, H

Yang, R

机构：

[1] Roche Research Center, Hoffmann - La Roche Inc., Nutley

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 31期

关键词：

D O I：

10.1016/0040-4039(96)01190-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and convergent synthesis of the leukotriene D-4 antagonist Ro24-5913 (9) has been developed that can serve both for technical production and combinatorial structure optimization. The synthesis of 6, achieved in 90% yield, is described. The conversion of 6 to 9 has been disclosed previously. Copyright (C) 1996 Elsevier Science Ltd

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页码：5445 / 5448

页数：4

相关论文

共 19 条

[1]

BAIMASHEV BA, 1993, RUSS J GEN CHEM, V63, P161

[2]

BAIMASHEV BA, Patent No. 1583425

[3] SYNTHESIS OF NATURAL ESTERS OF SUBSTITUTED CINNAMIC-ACIDS [J].

BANKOVA, VS .

JOURNAL OF NATURAL PRODUCTS, 1990, 53 (04) :821-824

[4]

Field G. F., 1991, US Patent, Patent No. [5,001,140,A1, 5001140]

[5] ERGOLINE PRECURSORS .2. AN EFFICIENT SYNTHESIS OF C-RING BY PALLADIUM (0) CATALYZED-REACTIONS [J].

GENET, JP ;

GRISONI, S .

TETRAHEDRON LETTERS, 1986, 27 (35) :4165-4168

[6] SYNTHESIS OF HETEROCYCLIC ALKENES BY HORNER REACTION [J].

KNOTT, EB .

JOURNAL OF THE CHEMICAL SOCIETY, 1965, (JUN) :3793-&

[7] KNOEVENAGEL, WITTIG AND WITTIG-HORNER REACTIONS IN THE PRESENCE OF MAGNESIUM-OXIDE OR ZINC-OXIDE [J].

MOISON, H ;

TEXIERBOULLET, F ;

FOUCAUD, A .

TETRAHEDRON, 1987, 43 (03) :537-542

[8] WITTIG-HORNER REACTIONS AND TRANSESTERIFICATION BY ANIONIC ACTIVATION OF C-H AND O-H BONDS IN A HETEROGENEOUS POTASSIUM CARBONATE-ALCOHOL SOLUTION [J].

MOULOUNGUI, Z ;

ELMESTOUR, R ;

DELMAS, M ;

GASET, A .

TETRAHEDRON, 1992, 48 (07) :1219-1232

[9] CESIUM CARBONATE IN WEAKLY HYDRATED SOLID-LIQUID HETEROGENEOUS MEDIUM - A NEW REAGENT FOR ANIONIC ACTIVATION SYNTHESIS [J].

MOULOUNGUI, Z ;

MURENGEZI, I ;

DELMAS, M ;

GASET, A .

SYNTHETIC COMMUNICATIONS, 1988, 18 (11) :1241-1245

[10]

ODONNELL M, 1991, J PHARMACOL EXP THER, V259, P751