Synthesis and structural characterization of 1,5-dimethyl-2-(S)(1′-phenylethyl)-2-aza-8-oxa-bicyclo[3.3.0]octane-3,7-dione

1, 5-Dimethyl-2-(S)-(1'-phenylethyl)-2-aza-8-oxa-bicyclo[3.3.0]octane-3, 7-dione was synthesized. The reaction of 2, 3-butanedione with malononitrile gave dimethyldicyano-bicyclolactam. Under acidic condition the lactam was hydrolyzed to dimethylbicyclolactone, which was converted with (S)-(-)-(1-phenylethyl)-amine into the target product. The structure was characterized by elemental analysis, 111, 1 H NMR and MS spectra. The crystal structure was determined by single-crystal X-ray diffraction analysis. The crystal belongs to monoclinic system with space group P2(1), unit cell dimensions: a = 0.8777 (18) nm, b = 1.0102 (2) run, c = 0.9009 (18) mn, beta = 118.75(3)degrees, V = 0.7003(2) nm(3), D-c = 1.296 g (.) cm(-3), mu = 0.089 mm(-1), F (000) = 292, Z = 2, R-1 = 0.0393, wR(2) = 0.0955.