Cognitive but Not Affective Theory of Mind Deficits in Progressive MS

被引:6
作者
Lancaster, Katie [1 ,2 ]
Stone, Eric M. [1 ]
Genova, Helen M. [1 ,2 ]
机构
[1] Kessler Fdn, W Orange, NJ USA
[2] Rutgers NJ Med Sch, Dept Phys Med & Rehabil, Newark, NJ USA
关键词
Multiple sclerosis; Social cognition; Progressive MS; Theory of mind; Ecological validity; Deficits; MS; Virtual reality; MULTIPLE-SCLEROSIS; SOCIAL COGNITION; FAUX PAS; MEMORY; RECOGNITION; ATTENTION;
D O I
10.1017/S1355617719000584
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: Social cognitive deficits are an important consequence of multiple sclerosis (MS), yet our understanding of how these deficits manifest in progressive MS is currently limited. To this end, we examined theory of mind (ToM) ability in a sample of individuals with progressive MS using an ecologically valid virtual assessment tool that allows for delineation of cognitive ToM (inferring thoughts and intentions of others) from affective ToM (inferring emotions of others). Methods & Results: We compared 15 individuals with progressive MS and 15 healthy controls on their ToM ability using the Virtual Assessment of Mentalising Ability. We found that, relative to healthy controls, participants with progressive MS were impaired in cognitive ToM, but not in affective ToM. Furthermore, we found that the MS participants' deficits in cognitive ToM were mediated by their general cognitive ability such that poor cognitive ToM ability in MS was explained by poor performance on tests of memory and processing speed. Conclusions: Our findings demonstrate that ToM deficits in progressive MS may be limited to cognitive ToM, while affective ToM is conserved. This could be attributable to the MS-related deficits in general cognitive ability, which appear to negatively affect only the cognitive component of ToM.
引用
收藏
页码:896 / 900
页数:5
相关论文
共 25 条
[1]   Neuroanatomical and neurochemical bases of theory of mind [J].
Abu-Akel, Ahmad ;
Shamay-Tsoory, Simone .
NEUROPSYCHOLOGIA, 2011, 49 (11) :2971-2984
[2]   Recognition of faux pas by normally developing children and children with Asperger syndrome or high-functioning autism [J].
Baron-Cohen, S ;
O'Riordan, M ;
Stone, V ;
Jones, R ;
Plaisted, K .
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 1999, 29 (05) :407-418
[3]   Theory of Mind and Executive Functions are Dissociated in Multiple Sclerosis [J].
Batista, Sonia ;
Freitas, Sandra ;
Afonso, Ana ;
Macario, Carmo ;
Sousa, Livia ;
Cunha, Luis ;
Santana, Isabel .
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY, 2018, 33 (05) :541-551
[4]   Brief International Cognitive Assessment for MS (BICAMS): international standards for validation [J].
Benedict, Ralph H. B. ;
Amato, Maria Pia ;
Boringa, Jan ;
Brochet, Bruno ;
Foley, Fred ;
Fredrikson, Stan ;
Hamalainen, Paivi ;
Hartung, Hans ;
Krupp, Lauren ;
Penner, Iris ;
Reder, Anthony T. ;
Langdon, Dawn .
BMC NEUROLOGY, 2012, 12
[5]   Revision of the brief visuospatial memory test: Studies of normal performance, reliability, and validity [J].
Benedict, RHB ;
Schretlen, D ;
Groninger, L ;
Dobraski, M ;
Shpritz, B .
PSYCHOLOGICAL ASSESSMENT, 1996, 8 (02) :145-153
[6]   Evaluation of a newly developed measure of theory of mind: The virtual assessment of mentalising ability [J].
Canty, Allana L. ;
Neumann, David L. ;
Fleming, Jennifer ;
Shum, David H. K. .
NEUROPSYCHOLOGICAL REHABILITATION, 2017, 27 (05) :834-870
[7]   Deficits in Social Cognition: An Unveiled Signature of Multiple Sclerosis [J].
Chalah, Moussa A. ;
Ayache, Samar S. .
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 2017, 23 (03) :266-286
[8]   Relationship between Social Cognition and traditional cognitive impairment in Progressive Multiple Sclerosis and possible implicated neuroanatomical regions [J].
Ciampi, E. ;
Uribe-San-Martin, R. ;
Vasquez, M. ;
Ruiz-Tagle, A. ;
Labbe, T. ;
Cruz, J. P. ;
Lillo, P. ;
Slachevsky, A. ;
Reyes, D. ;
Reyes, A. ;
Carcamo-Rodriguez, C. .
MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2018, 20 :122-128
[9]   Social cognition in multiple sclerosis A systematic review and meta-analysis [J].
Cotter, Jack ;
Firth, Joseph ;
Enzinger, Christian ;
Kontopantelis, Evangelos ;
Yung, Alison R. ;
Elliott, Rebecca ;
Drake, Richard J. .
NEUROLOGY, 2016, 87 (16) :1727-1736
[10]  
Delis D.C., 2000, Manual for the California Verbal Learning Test, (CVLT-II)