The aryl hydrocarbon receptor and the gut-brain axis

被引：89

作者：

Barroso, Andreia ^{[1
]}

Mahler, Joao Vitor ^{[1
,2
]}

Fonseca-Castro, Pedro Henrique ^{[1
,2
]}

Quintana, Francisco J. ^{[1
,3
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Ann Romney Ctr Neurol Dis, Boston, MA 02115 USA

[2] Univ Sao Paulo, Fac Med FMUSP, Sao Paulo, SP, Brazil

[3] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

来源：

CELLULAR & MOLECULAR IMMUNOLOGY | 2021年 / 18卷 / 02期

关键词：

Aryl hydrocarbon receptor; Autoimmune diseases; Infectious diseases; cancer; REGULATORY T-CELLS; AH RECEPTOR; DENDRITIC CELLS; ASTROCYTE ACTIVATION; DIOXIN RECEPTOR; AUTOIMMUNE ENCEPHALOMYELITIS; INTESTINAL INFLAMMATION; ENVIRONMENTAL-CONTROL; NUCLEAR-LOCALIZATION; HYDROXYLASE-ACTIVITY;

D O I：

10.1038/s41423-020-00585-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now recognized as a receptor for multiple physiological ligands, with important roles in health and disease. In this review, we discuss the role of AHR in the gut-brain axis and its potential value as a therapeutic target for immune-mediated diseases.

引用

页码：259 / 268

页数：10

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