The Si-2,4,6-trimethoxyphenyl moiety as a novel protecting group in organosilicon chemistry:: Alternative synthesis of rac-sila-venlafaxine

被引：31

作者：

Daiss, JO ^{[1
]}

Penka, M ^{[1
]}

Burschka, C ^{[1
]}

Tacke, R ^{[1
]}

机构：

[1] Univ Wurzburg, Inst Anorgan Chem, D-97074 Wurzburg, Germany

来源：

ORGANOMETALLICS | 2004年 / 23卷 / 21期

关键词：

D O I：

10.1021/om040087n

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The Si-2,4,6-trimethoxyphenyl (Si-2,4,6-TMOP) moiety is claimed to be an effective protecting group for synthetic organosilicon chemistry. To demonstrate its high synthetic potential, the Si-2,4,6-TMOP protecting group has been used for a novel multistep synthesis of rac-sila-venlafaxine (a sila-analogue of the serotonin/noradrenaline reuptake inhibitor rac-venlafaxine), starting from 1,1-dichloro-1-silacyclohexane. In addition, the Si-2,4,6-TMOP moiety has been used as a protecting group in silacyclobutane chemistry.

引用

页码：4987 / 4994

页数：8

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