Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities

被引：90

作者：

Song, Shuling ^{[1
,2
]}

Tchkonia, Tamara ^{[3
]}

Jiang, Jing ^{[4
]}

Kirkland, James L. ^{[3
]}

Sun, Yu ^{[1
,4
,5
,6
]}

机构：

[1] Chinese Acad Sci, Univ Chinese Acad Sci, Key Lab Tissue Microenvironm & Tumor, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China

[2] Binzhou Med Univ, Sch Gerontol, Yantai 264003, Shandong, Peoples R China

[3] Mayo Clin, Robert & Arlene Kogod Ctr Aging, Rochester, MN 55905 USA

[4] Binzhou Med Univ, Sch Pharm, Yantai 264003, Shandong, Peoples R China

[5] Univ Washington, Dept Med, Seattle, WA 98195 USA

[6] Univ Washington, VAPSHCS, Seattle, WA 98195 USA

来源：

ADVANCED SCIENCE | 2020年 / 7卷 / 23期

基金：

芬兰科学院; 中国国家自然科学基金; 美国国家卫生研究院;

关键词：

aging; clinical trials; healthspan; senescent cells; senolytics; senotherapy; DNA-DAMAGE RESPONSE; CELLULAR SENESCENCE; SECRETORY PHENOTYPE; CLEARANCE; TISSUE; RESISTANCE; INHIBITION; STRATEGIES; IMMUNOSURVEILLANCE; SURVEILLANCE;

D O I：

10.1002/advs.202002611

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aging is a physiological decline in both structural homeostasis and functional integrity, progressively affecting organismal health. A major hallmark of aging is the accumulation of senescent cells, which have entered a state of irreversible cell cycle arrest after experiencing inherent or environmental stresses. Although cellular senescence is essential in several physiological events, it plays a detrimental role in a large array of age-related pathologies. Recent biomedical advances in specifically targeting senescent cells to improve healthy aging, or alternatively, postpone natural aging and age-related diseases, a strategy termed senotherapy, have attracted substantial interest in both scientific and medical communities. Challenges for aging research are highlighted and potential avenues that can be leveraged for therapeutic interventions to control aging and age-related disorders in the current era of precision medicine.

引用

页数：14

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