Zinc-Mediated Formation of Trifluoromethyl Ethers from Alcohols and Hypervalent Iodine Trifluoromethylation Reagents

被引：261

作者：

Koller, Raffael ^{[1
]}

Stanek, Kyrill ^{[1
]}

Stolz, Daniel ^{[1
]}

Aardoom, Raphael ^{[1
]}

Niedermann, Katrin ^{[1
]}

Togni, Antonio ^{[1
]}

机构：

[1] ETH, Swiss Fed Inst Technol, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 24期

关键词：

etherification; synthetic methods; hypervalent compounds; iodine; trifluoromethylation; MILD ELECTROPHILIC TRIFLUOROMETHYLATION; MEDICINAL CHEMISTRY; SALTS; FLUORINE; ACIDS; FLUOROALKYLATION; SPECTROSCOPY; DIFFUSION; RILUZOLE; AGENTS;

D O I：

10.1002/anie.200900974

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A (fluor)ry of activity: The transfer of an intact trifluoromethyl group from a hypervalent iodine reagent to an aliphatic alcohol occurs smoothly upon activation by zinc bis(triflimide). This constitutes a straightforward method for the preparation of trifluoromethoxy alkyl derivatives, compounds otherwise difficult to access. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4332 / 4336

页数：5

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