Fluorinated phosphonates: Synthesis and biomedical application

This review covers the synthesis, fundamental chemical properties and biomedical uses of the phosphonic substituent on the organyl moiety. First, a survey of the synthetic methods used for the preparation of fluorinated phosphonates is given. Second, the different types of fluoro-phosphonates having significant biological importance are presented. Third, the use of fluorinated phosphonates in biomedical studies is described. Discussion of basic aspects of phosphonate and organofluorine chemistry is reduced to minimum to avoid redundancy.