Proapoptotic effect of Uncaria tomentosa extracts

被引：33
作者：
De Martino, Laura
Martinot, Jose Luis Silva
Franceschelli, Silvia
Leone, Arturo
Pizza, Cosimo
De Feo, Vincenzo
机构：
[1] Univ Salerno, Dipartimento Sci Farmaceut, I-84084 Fisciano, Salerno, Italy
[2] Lab Hersil SA, Lima, Peru
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 2006年 / 107卷 / 01期
关键词：
Uncaria tomentosa; MCF7; HeLa; SAOS; apoptosis; caspase3;
D O I：
10.1016/j.jep.2006.02.013
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Uncaria tomentosa ("Uha de gato") (Rubiaceae) is widely used in South America for treatment of gastritis, arthritis, cancer and inflammatory conditions. Recent literature reports cytostatic, antiproliferative, anti-inflammatory, mutagenic and anti-mutagenic properties of extracts of the plant. The present study investigates the possible proapoptotic mechanism via the activation of caspase3, in cytostatic effects of root bark extracts of Uncaria tomentosa on three different tumoral cell lines. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：91 / 94
页数：4
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