Regioselective Sonogashira Reactions of N-Methyltetrabromopyrrole: First Synthesis of Tri- and Tetra(1-alkynyl)pyrroles

被引：17

作者：

Ullah, Farman ^{[2
]}

Dang, Tung T. ^{[1
]}

Heinicke, Joachim ^{[2
]}

Villinger, Alexander ^{[1
]}

Langer, Peter ^{[1
,3
]}

机构：

[1] Univ Rostock, Inst Chem, D-18059 Rostock, Germany

[2] Ernst Moritz Arndt Univ Greifswald, Inst Biochem, D-17487 Greifswald, Germany

[3] Univ Rostock eV, Leibniz Inst Katalyse, D-18059 Rostock, Germany

来源：

SYNLETT | 2009年 / 05期

关键词：

catalysis; palladium; carbon-carbon bond formation; regioselectivity; pyrroles; CROSS-COUPLING REACTIONS; (&/-)-BONELLIN DIMETHYL ESTER; PYRROLE SYNTHESIS; FACILE SYNTHESIS; SUBSTITUTED PYRROLES; DERIVATIVES; 1,4-DIKETONES; HETEROCYCLES; CYCLIZATION; PRECURSORS;

D O I：

10.1055/s-0028-1087947

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Methyl-2,3,4,5-tetrabromopyrrole is transformed into a variety of alkynyl-substituted pyrroles by regioselective Sonogashira cross-coupling reactions. In this context, the synthesis of the first tri- and tetra(1-alkynyl)pyrroles is reported.

引用

页码：838 / 842

页数：5

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